N-(2-mercaptopropionyl)-glycine but not Allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorPires, Karla Maria Pereira-
Autor(es): dc.creatorBezerra, Frank Silva-
Autor(es): dc.creatorMachado, Mariana Nascimento-
Autor(es): dc.creatorZin, Walter Araújo-
Autor(es): dc.creatorPorto, Luís Cristóvão-
Autor(es): dc.creatorValença, Samuel dos Santos-
Data de aceite: dc.date.accessioned2019-11-06T13:26:03Z-
Data de disponibilização: dc.date.available2019-11-06T13:26:03Z-
Data de envio: dc.date.issued2013-01-30-
Data de envio: dc.date.issued2013-01-30-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/2103-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/555271-
Descrição: dc.descriptionWe investigated the possible protective effects of the Allopurinol (A), N-(2-mercaptopropionyl)-glycine (M) and N-acetylcysteine (N) against lung injury caused by long-term exposure to cigarette smoke (CS) in mouse. C57BL6 mice were exposed to 12 cigarettes a day for 60 days and concomitantly treated with either one of the antioxidant drugs diluted in saline (CS + A—50 mg/kg; CS + M—200 mg/kg/day; CS + N—200 mg/kg/day). Control groups were sham-smoked (AA). Long-term CS exposure results in extensive parenchyma destruction in CS group. Both CS + N and CS + M groups showed preserved alveolar structure and showed preserved lung function when compared to CS group. Macrophage and neutrophil counts were decreased in CS + M, and CS + N groups when compared to CS group (p < 0.05). Antioxidant enzyme activities were reduced in all treated groups. CS + A showed the highest reduction in catalase activity (−25%, p < 0.01). We conclude that M treatment reduced long-term CS-induced inflammatory lung parenchyma destruction and lung function, comparable to N treatment, however, antioxidant administration did not reverse CS-induced antioxidant enzyme activity reduction.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Respiratory Physiology & Neurobiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314940932402-
Palavras-chave: dc.subjectCigarette-
Palavras-chave: dc.subjectAlveolar space enlargement-
Palavras-chave: dc.subjectLung inflammation-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleN-(2-mercaptopropionyl)-glycine but not Allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse-
Aparece nas coleções:Repositório Institucional - UFOP

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