Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorChianca Júnior, Deoclécio Alves-
Autor(es): dc.creatorMachado, Benedito Honório-
Data de aceite: dc.date.accessioned2019-11-06T13:25:38Z-
Data de disponibilização: dc.date.available2019-11-06T13:25:38Z-
Data de envio: dc.date.issued2012-11-26-
Data de envio: dc.date.issued2012-11-26-
Data de envio: dc.date.issued1996-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1822-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/555132-
Descrição: dc.descriptionThe purpose of the present study was to evaluate whether or not cardiovagal excitatory and sympatho-inhibitory pathways of the Bezold-Jarischreflex at the NTS level were mediated by NMDA receptors. The Bezold-Jarischreflex was activated by intravenous (i.v.) injection of serotonin in consciousrats before and after microinjection of phosphonovaleric acid (AP-5), a selective NMDAantagonist, into the NTS. The Bezold-Jarischreflex was also activated before and after methyl-atropine (i.v.) in order to evaluate if the changes in mean arterial pressure were dependent on the bradycardic response. The data showed that AP-5 into the NTS produced a dose-dependent reduction in both bradycardic and hypotensive responses to activation of the Bezold-Jarischreflex. Methyl-atropine also blocked the bradycardic and hypotensive responses to Bezold-Jarischreflex activation. The data show that in consciousrats the cardiovagal component of the Bezold-Jarischreflex plays a major role in the cardiovascular changes produced by the activation of this reflex and suggest that the neurotransmission of the cardiovagal component of the Bezold-Jarischreflex is mediated by NMDA receptors.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Brain Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314370015968-
Palavras-chave: dc.subjectPhosphonovaleric acid-
Palavras-chave: dc.subjectSympatho-inhibition-
Palavras-chave: dc.subjectBradycardia-
Palavras-chave: dc.subjectC-fiber-
Palavras-chave: dc.subjectCardiopulmonary receptor-
Palavras-chave: dc.subjectAmino acid receptor-
Título: dc.titleMicroinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex-
Aparece nas coleções:Repositório Institucional - UFOP

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