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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Cardoso, Leonardo Máximo | - |
Autor(es): dc.creator | Pedrosa, Maria Lúcia | - |
Autor(es): dc.creator | Silva, Marcelo Eustáquio | - |
Autor(es): dc.creator | Moraes, Márcio Flávio Dutra | - |
Autor(es): dc.creator | Colombari, Eduardo | - |
Autor(es): dc.creator | Chianca Júnior, Deoclécio Alves | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:25:37Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:25:37Z | - |
Data de envio: dc.date.issued | 2012-11-26 | - |
Data de envio: dc.date.issued | 2012-11-26 | - |
Data de envio: dc.date.issued | 2005 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/123456789/1813 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/555128 | - |
Descrição: dc.description | Our hypothesis is that iron accumulated in tissue, rather than in serum, may compromise cardiovascular control. Male Fischer 344 rats weighing 180 to 220 g were divided into 2 groups. In the serum iron overload group (SIO, N = 12), 20 mg elemental iron was injected ip daily for 7 days. In the tissue iron overload group (TIO, N = 19), a smaller amount of elemental iron was injected (10 mg, daily) for 5 days followed by a resting period of 7 days. Reflex heart rate responses were elicited by iv injections of either phenylephrine (0.5 to 5.0 µg/kg) or sodium nitroprusside (1.0 to 10.0 µg/kg). Baroreflex curves were determined and fitted to sigmoidal equations and the baroreflex gain coefficient was evaluated. To evaluate the role of other than a direct effect of iron on tissue, acute treatment with the iron chelator deferoxamine (20 mg/kg, iv) was performed on the TIO group and the baroreflex was re-evaluated. At the end of the experiments, evaluation of iron levels in serum confirmed a pronounced overload for the SIO group (30-fold), in contrast to the TIO group (2-fold). Tissue levels of iron, however, were higher in the TIO group. The SIO protocol did not produce significant alterations in the baroreflex curve response, while the TIO protocol produced a nearly 2-fold increase in baroreflex gain (-4.34 ± 0.74 and -7.93 ± 1.08 bpm/mmHg, respectively). The TIO protocol animals treated with deferoxamine returned to sham levels of baroreflex gain (-3.7 ± 0.3 sham vs -3.6 ± 0.2 bpm/mmHg) 30 min after the injection. Our results indicate an effect of tissue iron overload on the enhancement of baroreflex sensitivity. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | No permission is required from the authors or the publishers download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. Fonte: http://www.bjournal.com.br/index.php?option=com_content&view=article&id=185&Itemid=139 Acesso em: 21/01/2014 | - |
Palavras-chave: dc.subject | Blood pressure | - |
Palavras-chave: dc.subject | Deferoxamine | - |
Palavras-chave: dc.subject | Iron dextran | - |
Palavras-chave: dc.subject | Baroreflex | - |
Palavras-chave: dc.subject | Iron overload | - |
Palavras-chave: dc.subject | Heart rate | - |
Título: dc.title | Baroreflex function in conscious rats submitted to iron overload. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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