Trypanosoma cruzi: treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorArantes, Jerusa Marilda-
Autor(es): dc.creatorPedrosa, Maria Lúcia-
Autor(es): dc.creatorMartins, Helen Rodrigues-
Autor(es): dc.creatorVeloso, Vanja Maria-
Autor(es): dc.creatorLana, Marta de-
Autor(es): dc.creatorBahia, Maria Terezinha-
Autor(es): dc.creatorTafuri, Washington Luiz-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Data de aceite: dc.date.accessioned2019-11-06T13:25:01Z-
Data de disponibilização: dc.date.available2019-11-06T13:25:01Z-
Data de envio: dc.date.issued2012-09-19-
Data de envio: dc.date.issued2012-09-19-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1406-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554930-
Descrição: dc.descriptionThe effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negative hemoculture and positive ELISA in the acute and chronic phases and positive PCR in the acute phase: in the chronic phase, three of the animals presented negative PCR. The single surviving infected/non-treated animal exhibited positive hemoculture, PCR and ELISA in both phases of infection. Infected groups presented lower levels of iron in the liver compared with treated/non-infected or non-treated/ non-infected animals. The serum iron levels of the infected/non-treated group were higher on the 21st day post-infection in comparison with control and infected/treated groups. These results suggest that decrease of iron in the host leads to T. cruzi infection attenuation.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990280591-
Título: dc.titleTrypanosoma cruzi: treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice.-
Aparece nas coleções:Repositório Institucional - UFOP

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