Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Neide Maria-
Autor(es): dc.creatorVieira, Júlio César Menezes-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorTafuri, Wagner Luiz-
Data de aceite: dc.date.accessioned2019-11-06T13:25:00Z-
Data de disponibilização: dc.date.available2019-11-06T13:25:00Z-
Data de envio: dc.date.issued2012-09-19-
Data de envio: dc.date.issued2012-09-19-
Data de envio: dc.date.issued2009-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1398-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554925-
Descrição: dc.descriptionIn order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420279890-
Palavras-chave: dc.subjectIFN-c-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectiNOS-
Palavras-chave: dc.subjectProtozoa-
Palavras-chave: dc.subjectToxoplasma gondii-
Palavras-chave: dc.subjectTNFRp55-
Título: dc.titleToxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection.-
Aparece nas coleções:Repositório Institucional - UFOP

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