ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorLucas Filho, Milton Dayrell-
Autor(es): dc.creatorSilva, Grazielle Caroline da-
Autor(es): dc.creatorCôrtes, Steyner de França-
Autor(es): dc.creatorMares Guia, Thiago Rennó dos-
Autor(es): dc.creatorFerraz, Vany Perpetua-
Autor(es): dc.creatorSerra, Carla Penido-
Autor(es): dc.creatorBraga, Fernão Castro-
Data de aceite: dc.date.accessioned2019-11-06T13:24:35Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:35Z-
Data de envio: dc.date.issued2012-07-30-
Data de envio: dc.date.issued2012-07-30-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1214-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554775-
Descrição: dc.descriptionErythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180657438.-
Palavras-chave: dc.subjectAstilbin-
Palavras-chave: dc.subjectErythroxylum gonocladum-
Palavras-chave: dc.subjectIn vitro ACE inhibitory activity-
Título: dc.titleACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.