Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorFerreira, Herick Campos-
Autor(es): dc.creatorSerra, Carla Penido-
Autor(es): dc.creatorEndringer, Denise Coutinho-
Autor(es): dc.creatorLemos, Virgínia Soares-
Autor(es): dc.creatorBraga, Fernão Castro-
Autor(es): dc.creatorCôrtes, Steyner de França-
Data de aceite: dc.date.accessioned2019-11-06T13:24:35Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:35Z-
Data de envio: dc.date.issued2012-07-30-
Data de envio: dc.date.issued2012-07-30-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1213-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554774-
Descrição: dc.descriptionThe vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was evaluated in superior mesenteric artery rings. HSE produced a concentration-dependent vasodilation (IC50 ¼ 10.874.0 mg/mL) in arterial rings pre-contracted with phenylephrine, which was completely abolished in endothelium-denuded vessels. Endothelium-dependent vasodilation induced by HSE was strongly reduced by L-NAME (100 mM), a nitric oxide (NO) synthase inhibitor, but neither by atropine, a muscarinic receptor antagonist (1 mM), nor by indomethacin (10 mM), a cyclooxygenase inhibitor. In rings pre-contracted with 80mM KCl, the vasodilator effect of HSE was shifted to the right and was completely abolished in the presence of L-NAME (100 mM). Similar effects were obtained in mesenteric rings pre-contracted with phenylephrine in the presence of KCl 25mM alone or in addition to 100 mM L-NAME.In addition, BaCl2 (1mM) dramatically reduced the vasodilation induced by HSE. Together, these findings led usv to conclude that HSE induces an endothelium-dependent vasodilation in rat mesenteric artery, by a mechanism dependent on NO, on the activation of potassium channels and endothelium-derived hyperpolarizing factor release. Rutin, identified as a major peak in the HPLC fingerprint obtained for HSE, might contribute for the observed vasodilator effect, since it was able to induce an endothelium-dependent vasodilation in rat superior mesenteric arteries.-
Idioma: dc.languageen-
Direitos: dc.rightsO periódico Phytomedicine concede permissão ao Repositório Institucional da UFOP para depositar este artigo. Número da Licença: 3233040896043-
Palavras-chave: dc.subjectEDHF-
Palavras-chave: dc.subjectHancornia speciosa-
Palavras-chave: dc.subjectResistance artery-
Palavras-chave: dc.subjectVasodilation-
Palavras-chave: dc.subjectEndothelium-
Palavras-chave: dc.subjectNitric oxide-
Título: dc.titleEndothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery.-
Aparece nas coleções:Repositório Institucional - UFOP

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