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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Ferreira, Herick Campos | - |
Autor(es): dc.creator | Serra, Carla Penido | - |
Autor(es): dc.creator | Endringer, Denise Coutinho | - |
Autor(es): dc.creator | Lemos, Virgínia Soares | - |
Autor(es): dc.creator | Braga, Fernão Castro | - |
Autor(es): dc.creator | Côrtes, Steyner de França | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:24:35Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:24:35Z | - |
Data de envio: dc.date.issued | 2012-07-30 | - |
Data de envio: dc.date.issued | 2012-07-30 | - |
Data de envio: dc.date.issued | 2007 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/123456789/1213 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/554774 | - |
Descrição: dc.description | The vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was evaluated in superior mesenteric artery rings. HSE produced a concentration-dependent vasodilation (IC50 ¼ 10.874.0 mg/mL) in arterial rings pre-contracted with phenylephrine, which was completely abolished in endothelium-denuded vessels. Endothelium-dependent vasodilation induced by HSE was strongly reduced by L-NAME (100 mM), a nitric oxide (NO) synthase inhibitor, but neither by atropine, a muscarinic receptor antagonist (1 mM), nor by indomethacin (10 mM), a cyclooxygenase inhibitor. In rings pre-contracted with 80mM KCl, the vasodilator effect of HSE was shifted to the right and was completely abolished in the presence of L-NAME (100 mM). Similar effects were obtained in mesenteric rings pre-contracted with phenylephrine in the presence of KCl 25mM alone or in addition to 100 mM L-NAME.In addition, BaCl2 (1mM) dramatically reduced the vasodilation induced by HSE. Together, these findings led usv to conclude that HSE induces an endothelium-dependent vasodilation in rat mesenteric artery, by a mechanism dependent on NO, on the activation of potassium channels and endothelium-derived hyperpolarizing factor release. Rutin, identified as a major peak in the HPLC fingerprint obtained for HSE, might contribute for the observed vasodilator effect, since it was able to induce an endothelium-dependent vasodilation in rat superior mesenteric arteries. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O periódico Phytomedicine concede permissão ao Repositório Institucional da UFOP para depositar este artigo. Número da Licença: 3233040896043 | - |
Palavras-chave: dc.subject | EDHF | - |
Palavras-chave: dc.subject | Hancornia speciosa | - |
Palavras-chave: dc.subject | Resistance artery | - |
Palavras-chave: dc.subject | Vasodilation | - |
Palavras-chave: dc.subject | Endothelium | - |
Palavras-chave: dc.subject | Nitric oxide | - |
Título: dc.title | Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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