Carbonyl cyanidem - chlorophenylhydrazone induced calcium signalingandactivationofplasmamembraneH1-ATPaseintheyeast Saccharomyces cerevisiae.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorPereira, Michele B. P.-
Autor(es): dc.creatorTisi, Renata-
Autor(es): dc.creatorFietto, Luciano Gomes-
Autor(es): dc.creatorCardoso, Anamaria de Souza-
Autor(es): dc.creatorFrança, Mônica M.-
Autor(es): dc.creatorCarvalho, Fernanda Machado de-
Autor(es): dc.creatorTrópia, Maria José Magalhães-
Autor(es): dc.creatorMartegani, Enzo-
Autor(es): dc.creatorCastro, Ieso de Miranda-
Autor(es): dc.creatorBrandão, Rogélio Lopes-
Data de aceite: dc.date.accessioned2019-11-06T13:24:29Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:29Z-
Data de envio: dc.date.issued2012-07-18-
Data de envio: dc.date.issued2012-07-18-
Data de envio: dc.date.issued2008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1164-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554737-
Descrição: dc.descriptionThe plasma membrane H1-ATPase from Saccharomyces cerevisiae is an enzyme that plays a very important role in the yeast physiology. The addition of protonophores, such as 2,4-dinitrophenol (DNP) and carbonyl cyanide m-chlorophenylhydrazone (CCCP), also triggers a clear in vivo activation of this enzyme. Here, we demonstrate that CCCP-induced activation of the plasma membrane H1-ATPase shares some similarities with the sugar-induced activation of the enzyme. Phospholipase C and protein kinase C activities are essential for this activation process while Gpa2p, a G protein involved in the glucose-induced activation of the ATPase, is not required. CCCP also induces a phospholipase Cdependent increase in intracellular calcium. Moreover, we show that the availability of extracellular calcium is required for CCCP stimulation of H1-ATPase, suggesting a possible connection between calcium signaling and activation of ATPase.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico FEMS Yeast Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 500810576.-
Palavras-chave: dc.subjectDepolarizing compounds-
Palavras-chave: dc.subjectSaccharomyces cerevisiae-
Palavras-chave: dc.subjectPlasma membrane H1-ATPase-
Título: dc.titleCarbonyl cyanidem - chlorophenylhydrazone induced calcium signalingandactivationofplasmamembraneH1-ATPaseintheyeast Saccharomyces cerevisiae.-
Aparece nas coleções:Repositório Institucional - UFOP

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