Apolipoprotein e polymorphism in brazilian dyslipidemic individuals: Ouro Preto study.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLana, Angelo Mendes-
Autor(es): dc.creatorPena, Geórgia das Graças-
Autor(es): dc.creatorFreitas, Silvia Nascimento de-
Autor(es): dc.creatorLima, Angélica Alves-
Autor(es): dc.creatorNicolato, Roney Luiz de Carvalho-
Autor(es): dc.creatorNascimento Neto, Raimundo Marques do-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorFreitas, Renata Nascimento de-
Data de aceite: dc.date.accessioned2019-11-06T13:24:19Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:19Z-
Data de envio: dc.date.issued2012-07-12-
Data de envio: dc.date.issued2012-07-12-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1092-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554685-
Descrição: dc.descriptionThe influence of apolipoprotein E alleles and genotypes on plasma lipid levels was determined in 185 individuals of mixed ethnicity living in Ouro Preto, Brazil. DNA was obtained from blood samples and the genotypes were determined by an RFLP-PCR procedure. The *3 allele was the most frequent (72%), followed by *4 (20%) and *2 (8%); *4 frequency was higher and *2 frequency was lower in the dyslipidemic group than in the normal control group. The *2 carriers presented lower LDL and total cholesterol levels compared to the *3 and *4 carriers. All six expected genotypes were observed in the individuals genotyped: E2/2 (2.1%), E4/4 (2.7%), E2/4 (3.7%), E2/3 (8.0%), E3/3 (53.3%), E3/4 (29.9%); no difference in genotype frequencies was found between the normal and dyslipidemic groups. Compared with *2, the presence of *3 increases more than two times the risk for dyslipidemia (OR = 2.31; P = 0.025; 95% CI = 1.06-5.06) and the presence of *4 increases it three times (OR = 3.31; P = 0.006; 95% CI = 1.36-8.04). The only significant effect of genotype was an increased risk for dyslipidemia in the *4 genotype carriers (E3/4 + E4/ 4) compared with the *2 genotype carriers (E2/2 + E2/3) with OR = 3.69 (95% CI = 1.25-10.88). The present study indicates that in the Ouro Preto admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.-
Idioma: dc.languageen-
Direitos: dc.rightsNo permission is required from the authors or the publishers download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. Fonte: http://www.bjournal.com.br/index.php?option=com_content&view=article&id=185&Itemid=139 Acesso em: 21/01/2014-
Palavras-chave: dc.subjectBrazilian population-
Palavras-chave: dc.subjectAtherosclerosis-
Palavras-chave: dc.subjectApolipoprotein E polymorphism-
Palavras-chave: dc.subjectLipids-
Palavras-chave: dc.subjectDyslipidemia-
Título: dc.titleApolipoprotein e polymorphism in brazilian dyslipidemic individuals: Ouro Preto study.-
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