Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMaciel, Naira Rezende-
Autor(es): dc.creatorReis, Priscila Gomes dos-
Autor(es): dc.creatorKato, Kelly Cristina-
Autor(es): dc.creatorVidal, Alessandra Teixeira-
Autor(es): dc.creatorGuimarães, Homero Nogueira-
Autor(es): dc.creatorFrezard, Frederic Jean Georges-
Autor(es): dc.creatorBarcellos, Neila Marcia Silva-
Autor(es): dc.creatorGuimarães, Andrea Grabe-
Data de aceite: dc.date.accessioned2019-11-06T13:24:16Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:16Z-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1055-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554670-
Descrição: dc.descriptionTrivalent antimonial drugs, including tartar emetic (TA), are known to induce important cardiotoxicity observed by electrocardiographic abnormalities. Liposome encapsulation was found to reduce the overall acute toxicity of TA. The present work investigated the cardiovascular parameters alterations of rats submitted to the treatment with free and encapsulated TA in long-circulating liposomes. Liposomes were made using lipids DSPC, DSPE-PEG and cholesterol. The cardiovascular signals, electrocardiogram (ECG) and arterial blood pressure (AP), were recorded from anaesthetized Wistar rats after intravenous (IV) administration of a single specially high dose (17 mg/kg) of TA in liposomes and in free form. The IV administration of TA solution caused significant increase of QT interval of ECG and significant reduction of AP when compared to the control group. These alterations were not observed when liposomes TA were administered and the profile of ECG and AP data was quite similar to the control groups. In conclusion, a liposomal formulation of TA showed a reduced cardiotoxic profile for TA when compared to the free form.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Toxicology Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285430049485.-
Palavras-chave: dc.subjectArterial pressure-
Palavras-chave: dc.subjectCardiotoxicity-
Palavras-chave: dc.subjectAntimonial tartrate-
Palavras-chave: dc.subjectLong-circulating liposomes-
Palavras-chave: dc.subjectECG-
Título: dc.titleReduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats.-
Aparece nas coleções:Repositório Institucional - UFOP

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