Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected byLeishmania (Leishmania) chagasi.

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Autor(es): dc.creatorReis, Alexandre Barbosa-
Autor(es): dc.creatorCarvalho, Andréa Teixeira de-
Autor(es): dc.creatorVale, André Macedo-
Autor(es): dc.creatorMarques, Marcos José-
Autor(es): dc.creatorGiunchetti, Rodolfo Cordeiro-
Autor(es): dc.creatorMayrink, Wilson-
Autor(es): dc.creatorGuerra, Luanda Liboreiro-
Autor(es): dc.creatorAndrade, Renata Aline de-
Autor(es): dc.creatorOliveira, Rodrigo Corrêa de-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Data de aceite: dc.date.accessioned2019-11-06T13:24:16Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:16Z-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1056-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554669-
Descrição: dc.descriptionThe role of anti-leishmanial immune response underlying the susceptibility/resistance during canine visceral leishmaniasis (CVL) has been recognized throughout ex vivo and in vitro investigations. Recently, we demonstrated that immunoglobulin levels (Igs), as well as the parasite load are relevant hallmarks of distinct clinical status of CVL. To further characterize and upgrade the background on this issue, herein, we have evaluated, inLeishmania ( Leishmania ) chagasinaturally infected dogs, the relationship between tissue parasitism (skin, bone marrow, spleen, liver and lymph node), the CVL clinical status (asymptomatic (AD), with no suggestive signs of the disease; oligosymptomatic (OD), with maximum three clinical signs—opaque bristles; localized alopecia and moderate loss of weight; symptomatic (SD), serologically positive with severe clinical signs of visceral leishmaniasis), and the humoral immunological profile of anti-Leishmania immunoglobulins (IgG, IgG1, IgG2, IgM, IgA and IgE). Our major statistically significant findings revealed distinct patterns of tissue parasite density within L. chagasi-infected dogs despite their clinical status, pointing out the spleen and skin as the most relevant sites of high parasitism during ongoing CVL. Parasite density of bone marrow and spleen were the most reliable parasitological markers to decode the clinical status of CVL. Moreover, the parasite density of bone marrow better correlates with most anti- Leishmania Igs reactivity. Additionally, a prognostic hallmark for canine visceral leishmaniasis was found, highlighting strong correlation between IgG1 and asymptomatic disease, but with IgA, IgE and IgG2 displaying better association with symptomatic disease. The new aspects of this study highlighted pioneer findings that correlated the degree of tissue parasite density (low (LP), medium (MP) and high (HP) parasitism) with distinct patterns of anti- Leishmania Igs reactivity. In this scope, our data re-enforce the anti- Leishmania IgG but with IgA reactivity as the better marker for overall tissue parasitism. The association between clinical status, Ig profile and the tissue parasitism support a novel investigation on the impact of humoral immune response and susceptibility/resistance mechanism during ongoing CVL-
Direitos: dc.rightsO Periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410158044-
Palavras-chave: dc.subjectCanine visceral leishmaniasis-
Palavras-chave: dc.subjectClinical forms-
Palavras-chave: dc.subjectTissue parasitism-
Palavras-chave: dc.subjectIg profile-
Palavras-chave: dc.subjectLeishmania chagasi-
Título: dc.titleIsotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected byLeishmania (Leishmania) chagasi.-
Aparece nas coleções:Repositório Institucional - UFOP

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