Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Leite, Elaine Amaral | - |
Autor(es): dc.creator | Guimarães, Andrea Grabe | - |
Autor(es): dc.creator | Guimarães, Homero Nogueira | - |
Autor(es): dc.creator | Coelho, George Luiz Lins Machado | - |
Autor(es): dc.creator | Barratt, Gillian | - |
Autor(es): dc.creator | Mosqueira, Vanessa Carla Furtado | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:24:15Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:24:15Z | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2007 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/123456789/1053 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/554667 | - |
Descrição: dc.description | The main objective of the present study was to evaluate the reduction in halofantrine (Hf) toxicity, an antimalarial drug frequently associated with QT interval prolongation in electrocardiogram, by its entrapment in poly-ε-caprolactone nanocapsules (NC). The acute lethal dose (LD100) of Hf.HCl experimentally observed was 200 mg/kg whereas the calculated LD50 was 154 mg/kg. In contrast, the LD100 for Hf-NC was 300 mg/ kg with a longer mean time to death than Hf.HCl. The calculated LD50 was 249 mg/kg for Hf-NC. The Hf entrapped in PCL NC presented a greater efficacy than PLA-PEG NC and than Hf solution in P. berghei-infected mice at 1 mg/kg. The cardiovascular parameters, ECG and arterial blood pressure, were evaluated in anaesthetized Wistar rats after the IV administration of a single, especially high dose (100 and 150 mg/kg) of halofantrine base loaded-nanocapsules (Hf-NC) or halofantrine chlorhydrate (Hf.HCl) solution. It was observed that Hf solution caused prolongation of the QT and PR intervals of the ECG; however, this effect was significantly (Pb0.001) reduced when Hf was administered entrapped in nanocapsules. The treatment with Hf.HCl induced a pronounced bradycardia and severe hypotension leading to death. The effect of Hf-NC upon heart rate was reduced from 58 to 75% for 100 and 150 mg/kg, respectively, when compared with Hf.HCl solution. These findings show that the encapsulation of halofantrine reduces the QT interval prolongation of ECG in rats and suggest that a modification of drug distribution was possible by using nanocapsules. Hf encapsulation was the main factor responsible for the significant reduction in cardiac toxicity observed. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O Periódico Life Sciences concede permissão para depósito do artigo no Repositório Institucional da UFOP. Número da licença: 3285421187900. | - |
Palavras-chave: dc.subject | Cardiotoxicity | - |
Palavras-chave: dc.subject | Lipophilic drug | - |
Palavras-chave: dc.subject | QT interval prolongation | - |
Palavras-chave: dc.subject | Halofantrine | - |
Palavras-chave: dc.subject | Nanocapsules | - |
Palavras-chave: dc.subject | Drug carriers | - |
Título: dc.title | Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: