Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorGiunchetti, Rodolfo Cordeiro-
Autor(es): dc.creatorOliveira, Rodrigo Corrêa de-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Autor(es): dc.creatorCarvalho, Andréa Teixeira de-
Autor(es): dc.creatorRoatt, Bruno Mendes-
Autor(es): dc.creatorSoares, Rodrigo Dian de Oliveira Aguiar-
Autor(es): dc.creatorSouza, Juliana Vitoriano de-
Autor(es): dc.creatorMoreira, Nádia das Dores-
Autor(es): dc.creatorMalaquias, Luiz Cosme Cotta-
Autor(es): dc.creatorCastro, Luciana Lisboa Mota e-
Autor(es): dc.creatorLana, Marta de-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Data de aceite: dc.date.accessioned2019-11-06T13:24:14Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:14Z-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1039-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554656-
Descrição: dc.descriptionCellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti- Leishmania IgG isotypes, together with higher levels of lymphocytes, particularly of circulating CD8 + T-lymphocytes and Leishmania chagasi antigen-specific CD8 + T-lymphocytes. As indicated by the intense cell proliferation and increased nitric oxide production during in vitro stimulation by L. chagasisoluble antigens, the candidate vaccine elicited an immune activation status potentially compatible with effective control of the etiological agent of CVL.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410072386-
Palavras-chave: dc.subjectCanine visceral leishmaniasis-
Palavras-chave: dc.subjectSaponin adjuvant-
Palavras-chave: dc.subjectCelland humoral immune response-
Título: dc.titleImmunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.-
Aparece nas coleções:Repositório Institucional - UFOP

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