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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Carneiro, Cláudia Martins | - |
Autor(es): dc.creator | Martins Filho, Olindo Assis | - |
Autor(es): dc.creator | Reis, Alexandre Barbosa | - |
Autor(es): dc.creator | Veloso, Vanja Maria | - |
Autor(es): dc.creator | Araújo, Flávio Marcos Gomes de | - |
Autor(es): dc.creator | Bahia, Maria Terezinha | - |
Autor(es): dc.creator | Lana, Marta de | - |
Autor(es): dc.creator | Coelho, George Luiz Lins Machado | - |
Autor(es): dc.creator | Gazzinelli, Giovanni | - |
Autor(es): dc.creator | Oliveira, Rodrigo Corrêa de | - |
Autor(es): dc.creator | Tafuri, Wagner Luiz | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:24:13Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:24:13Z | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2007 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/123456789/1036 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/554655 | - |
Descrição: dc.description | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reduction | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O Periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506 | - |
Palavras-chave: dc.subject | Dog | - |
Palavras-chave: dc.subject | Blood (BT) and metacycling (MT) trypomastigotes | - |
Palavras-chave: dc.subject | Trypanosoma cruzi | - |
Palavras-chave: dc.subject | Flow cytometry | - |
Título: dc.title | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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