Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Autor(es): dc.creatorVeloso, Vanja Maria-
Autor(es): dc.creatorAraújo, Flávio Marcos Gomes de-
Autor(es): dc.creatorBahia, Maria Terezinha-
Autor(es): dc.creatorLana, Marta de-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorGazzinelli, Giovanni-
Autor(es): dc.creatorOliveira, Rodrigo Corrêa de-
Autor(es): dc.creatorTafuri, Wagner Luiz-
Data de aceite: dc.date.accessioned2019-11-06T13:24:13Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:13Z-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2012-07-10-
Data de envio: dc.date.issued2007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1036-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554655-
Descrição: dc.descriptionDifferential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reduction-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectBlood (BT) and metacycling (MT) trypomastigotes-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Palavras-chave: dc.subjectFlow cytometry-
Título: dc.titleDifferential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs.-
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