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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Lage, Ramon Silva | - |
Autor(es): dc.creator | Oliveira, Guilherme Corrêa de | - |
Autor(es): dc.creator | Busek, Solange Cristina Uber | - |
Autor(es): dc.creator | Guerra, Luanda Liboreiro | - |
Autor(es): dc.creator | Giunchetti, Rodolfo Cordeiro | - |
Autor(es): dc.creator | Oliveira, Rodrigo Corrêa de | - |
Autor(es): dc.creator | Reis, Alexandre Barbosa | - |
Data de aceite: dc.date.accessioned | 2019-11-06T13:24:13Z | - |
Data de disponibilização: dc.date.available | 2019-11-06T13:24:13Z | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2012-07-10 | - |
Data de envio: dc.date.issued | 2007 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/123456789/1027 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/554652 | - |
Descrição: dc.description | Recent studies suggest that asymptomatic dogs infected with canine visceral leishmaniasis (CVL) develop a Th1 immunological profile whilst oligosymptomatic and symptomatic CVL-infected animals present a Th2 profile. In the present study, an RT-PCR method has been standardised and employed to evaluate the frequency and the semi-quantitative level of expression of the cytokines IL-4, IL-10, IL-12, INF- g and TNF- a in splenocytes of 30 dogs naturally infected with Leishmania chagasiand of 7 non-infected dogs (NID). An increase in the level of expression of IL-12 ( p = 0.059) was detected in all CVL-infected dogs compared with NID. In dogs exhibiting high parasitism, the frequency of expression of IL-10 was higher ( p = 0.011) than in animals presenting low parasitism or medium parasitism (MP) and in NID animals, whilst the level of expression of IL-10 was higher (p = 0.0094) than in animals exhibiting MP and in the NID group. Positive correlations between the levels of expression of IL-10 with respect to the progression of the disease (IL-10: r = 0.3510; p = 0.0337) and the levels of expression of IL-10 and INF- g increase in parasitism (IL-10: r = 0.3428; p = 0.0438 and INF- g: r = 0.4690; p = 0.0045) were observed. Such data suggest that CVL is marked by a balanced production of Th1 and Th2 cytokines, with a predominant accumulation of IL-10 as a consequence of an increase in parasitic load and progression of the disease, and INF- g was related with the increase in parasitic load. | - |
Idioma: dc.language | en | - |
Direitos: dc.rights | O Periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3303250782673 | - |
Palavras-chave: dc.subject | Cytokines | - |
Palavras-chave: dc.subject | RT-PCR | - |
Palavras-chave: dc.subject | Canine disease | - |
Palavras-chave: dc.subject | Visceral leishmaniasis | - |
Palavras-chave: dc.subject | Leishmania chagasi | - |
Título: dc.title | Analysis of the cytokine profile in spleen cells from dogs naturally infected by Leishmania chagasi. | - |
Aparece nas coleções: | Repositório Institucional - UFOP |
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