Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMaximiano, Flávia Pires-
Autor(es): dc.creatorPaula, Lívia Maria de-
Autor(es): dc.creatorFigueiredo, Vivian Paulino-
Autor(es): dc.creatorAndrade, Isabel Mayer de-
Autor(es): dc.creatorTalvani, André-
Autor(es): dc.creatorBarreto, Lívia Cristina Lira de Sá-
Autor(es): dc.creatorBahia, Maria Terezinha-
Autor(es): dc.creatorCunha Filho, Marcílio Sérgio Soares da-
Data de aceite: dc.date.accessioned2019-11-06T13:24:12Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:12Z-
Data de envio: dc.date.issued2012-07-09-
Data de envio: dc.date.issued2012-07-09-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/1007-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554646-
Descrição: dc.descriptionBenznidazole (BNZ) is traditionally used to treat Chagas disease. Despite its common use, BNZ has a poor water solubility and a variable bioavailability. The purpose of this study was to prepare BNZ microcrystals by solvent change precipitation and to study the effects of BNZ micronisation on therapeutic efficiency using a murine model of Chagas disease. The solvent change precipitation procedure was optimised in order to obtain stable and homogeneous particles with a small particle size, high yield and fast dissolution rate. The thermal and crystallographic analysis showed no polymorphic change in the microcrystals, and microscopy confirmed a significant reduction in particle size. A marked improvement in the drug dissolution rate was observed for micronised BNZ particles and BNZ tablets in comparison with untreated BNZ and commercial Rochagan_. In vivo studies showed a significant increase in the therapeutic efficacy of the BNZ microparticles, corroborating the dissolution results.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico European Journal of Pharmaceutics and Biopharmaceutics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3332590456764-
Palavras-chave: dc.subjectDissolution rate-
Palavras-chave: dc.subjectMicrocrystals-
Palavras-chave: dc.subjectBenznidazole-
Palavras-chave: dc.subjectChagas' disease-
Palavras-chave: dc.subjectSolvent change precipitation-
Título: dc.titleBenznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.-
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