Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAraújo, Márcio Sobreira Silva-
Autor(es): dc.creatorAndrade, Renata Aline de-
Autor(es): dc.creatorVianna, Leonardo Rocha-
Autor(es): dc.creatorMayrink, Wilson-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Autor(es): dc.creatorAvelar, Renato Sathler-
Autor(es): dc.creatorCarvalho, Andréa Teixeira de-
Autor(es): dc.creatorAndrade, Mariléia Chaves-
Autor(es): dc.creatorMelo, Maria Norma-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Data de aceite: dc.date.accessioned2019-11-06T13:24:11Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:11Z-
Data de envio: dc.date.issued2012-07-05-
Data de envio: dc.date.issued2012-07-05-
Data de envio: dc.date.issued2008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/986-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554639-
Descrição: dc.descriptionPhenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement of monocytes, Leishmune ® induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4 + T-cells with transient activation of CD8 + T-cell, besides decreased frequency of B-cell expressing-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291401473802-
Palavras-chave: dc.subjectCanine visceral leishmaniasis-
Palavras-chave: dc.subjectLeishvaccine-
Palavras-chave: dc.subjectLeishmune-
Palavras-chave: dc.subjectLymphocyte phenotypes-
Título: dc.titleDespite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.-
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