Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAraújo, Márcio Sobreira Silva-
Autor(es): dc.creatorAndrade, Renata Aline de-
Autor(es): dc.creatorAvelar, Renato Sathler-
Autor(es): dc.creatorMagalhães, Camila Paula-
Autor(es): dc.creatorCarvalho, Andréa Teixeira de-
Autor(es): dc.creatorAndrade, Mariléia Chaves-
Autor(es): dc.creatorCampolina, Sabrina Sidney-
Autor(es): dc.creatorMelo, Maria Norma-
Autor(es): dc.creatorVianna, Leonardo Rocha-
Autor(es): dc.creatorMayrink, Wilson-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Autor(es): dc.creatorMalaquias, Luiz Cosme Cotta-
Autor(es): dc.creatorRocha, Luciana Morais-
Autor(es): dc.creatorMartins Filho, Olindo Assis-
Data de aceite: dc.date.accessioned2019-11-06T13:24:06Z-
Data de disponibilização: dc.date.available2019-11-06T13:24:06Z-
Data de envio: dc.date.issued2012-07-04-
Data de envio: dc.date.issued2012-07-04-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/954-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554612-
Descrição: dc.descriptionIn this study, we summarized the major phenotypic/functional aspects of circulating leuko-cytes following canine immunization with Leishvaccine and Leishmune ®. Our findings showed that Leishvaccine triggered early changes in the innate immunity (neutrophils and eosinophils) with late alterations on monocytes. Conversely, Leishmune ® induced early phenotypic changes in both, neutrophils and monocytes. Moreover, Leishvaccine triggered mixed activation-related phenotypic changes on T-cells (CD4 + and CD8 +) and B-lymphocytes, hereas Leishmune® promoted a selective response, mainly associated with CD8 + T-cell activation. Mixed cytokine profile (IFN- /IL-4) was observed in Leishvaccine immunized dogs whereas a selective pro-inflammatory pattern (IFN- /NO) was induced by Leishmune ® vaccination. The distinct immunological profile triggered by Leishvaccine and Leishmune ® may be a direct consequence of the distinct biochemical composition of these immunobiological, i.e. complex versus purified Leishmaniaantigen along with Bacillus Calmette-Guérin (BCG) versus saponin adjuvant. Both immunobiologicals are able to acti-vate phagocytes and CD8 + T-cells and therefore could be considered as a putative vaccines against canine visceral leishmaniasis (CVL)-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3287141001258-
Título: dc.titleImmunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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