Vascular effects of 7-epiclusianone, a prenylated benzophenone from Rheedia gardneriana, on the rat aorta

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCruz, Allan Jefferson-
Autor(es): dc.creatorSantos, Marcelo Henrique dos-
Autor(es): dc.creatorNagem, Tanus Jorge-
Autor(es): dc.creatorCôrtes, Steyner de França-
Data de aceite: dc.date.accessioned2019-11-06T13:23:50Z-
Data de disponibilização: dc.date.available2019-11-06T13:23:50Z-
Data de envio: dc.date.issued2012-05-23-
Data de envio: dc.date.issued2012-05-23-
Data de envio: dc.date.issued2006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/775-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554538-
Descrição: dc.descriptionThe vascular effects of 7-epiclusianone on the rat aorta were investigated. In the rat aortic rings with functional endothelia, 7-epiclusianone up to 10mM induced a concentration-dependent vasodilatation of the sustained con tractions induced by phenylephrine (0.3mM). At concentrations higher than 10mM, 7-epiclusianone induced a concentration-dependent contraction in the aortic rings . The vasodilator effect of 7 -epiclusianone was drastically decreased with L-NAME (100m M) as well as in endothelium-denuded aortic rings. Moreover, indo methacin (10mM) induced a significant shift to the left in the vasodilator but did not modify the vasoconstrictor effect of 7-epiclusianone. In arteries without pre-contraction, 7-epi clusianone (3–100 m M) induced concentration-dependent contraction only in endothelium- intact an d in the presence of L-NAM E (100 m M). This effect was inhibited by indomet hacin (10mM ) and ZM2 30487 (1 mM), selective inhibitors of cyclooxygenase and of 5-lipoxygenase, respectively. We can conclude that at low concentrations 7 -epiclusianone induces an endothelium-dependent vasodilator effect in rat aortic rings . At higher concentrations an d in conditions where NO synthase was inhibited, 7-epiclusianone induces a vasocontractile effect. Nitric oxide seems to participate in the vasodilatation , while endothelial cyclooxygenase and 5 -lipoxygenase-derived products play a role in the vasoconstrictor effect.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3490231025847-
Palavras-chave: dc.subjectRheedia gardneriana-
Palavras-chave: dc.subjectBenzophenone-
Palavras-chave: dc.subjectEndothelium-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectLipoxygenases-
Palavras-chave: dc.subjectCyclooxigenase-
Título: dc.titleVascular effects of 7-epiclusianone, a prenylated benzophenone from Rheedia gardneriana, on the rat aorta-
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