Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCâmara, Diógenes Vadim-
Autor(es): dc.creatorLemos, Virgínia Soares-
Autor(es): dc.creatorSantos, Marcelo Henrique dos-
Autor(es): dc.creatorNagem, Tanus Jorge-
Autor(es): dc.creatorCôrtes, Steyner de França-
Data de aceite: dc.date.accessioned2019-11-06T13:23:49Z-
Data de disponibilização: dc.date.available2019-11-06T13:23:49Z-
Data de envio: dc.date.issued2012-05-22-
Data de envio: dc.date.issued2012-05-22-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/123456789/762-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/554533-
Descrição: dc.descriptionMechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3490231006877-
Palavras-chave: dc.subjectXanthone-
Palavras-chave: dc.subjectProtein kinase C-
Palavras-chave: dc.subjectResistance artery-
Palavras-chave: dc.subjectVasodilatation-
Título: dc.titleMechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries-
Aparece nas coleções:Repositório Institucional - UFOP

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