Model of a depolymerizing microtubule [Microtubule depolymerization as a biological machine]

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMcIntosh, J. Richard-
Autor(es): dc.creatorMolodtsov, Maxim-
Autor(es): dc.creatorAtaullakhanov, Fazly I.-
Autor(es): dc.creatorGrishchuk, Ekaterina L.-
Autor(es): dc.creatorEfremov, Artem-
Data de aceite: dc.date.accessioned2019-08-21T18:25:52Z-
Data de disponibilização: dc.date.available2019-08-21T18:25:52Z-
Data de envio: dc.date.issued2016-10-26-
Data de envio: dc.date.issued2016-10-26-
Fonte completa do material: dc.identifierhttp://acervodigital.unesp.br/handle/unesp/365505-
Fonte completa do material: dc.identifierhttp://objetoseducacionais2.mec.gov.br/handle/mec/22854-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/471711-
Descrição: dc.descriptionThis video shows the shortening plus end of a microtubule polymer with 13 protofilaments, which are arranged in a 3-start left handed helix (the most common configuration in cells). Tubulin dimers, consisting of alpha-tubulin (dark green) and beta-tubulin (light green), form a hollow tube 25 nm in a diameter. In this molecular-mechanical model of a microtubule each tubulin interacts via defined energy relationships with its longitudinal and lateral neighbors. The calculations begin with an initial configuration in which all protofilaments are perfectly straight. However, the minimum energy configuration for each pair of longitudinally attached tubulins is when they form roughly 22 degree angle. As a result, each protofilament tends to curl and form a 'ram's horn'. Tubulin dimers begin to dissociate from the protofilaments ends soon after they loose their lateral bonds (in the model the dissociation of the terminal dimer takes place when it bends greater than 90 degrees away from the microtubule axis)-
Descrição: dc.descriptionComponente Curricular::Educação Superior::Ciências Biológicas::Morfologia-
Publicador: dc.publisherThe American Society for Cell Biology, ASBC Image & Video Library-
Relação: dc.relationVideo 1. Model of a Depolymerizing Microtubule.mov-
Direitos: dc.rightsYou may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes-
Palavras-chave: dc.subjectTubulin dimer-
Palavras-chave: dc.subjectAlpha-tubulin-
Palavras-chave: dc.subjectBeta-tubulin-
Palavras-chave: dc.subjectDepolymerizing microtubule-
Palavras-chave: dc.subjectEducação Superior::Ciências Biológicas::Morfologia::Citologia e Biologia Celular-
Título: dc.titleModel of a depolymerizing microtubule [Microtubule depolymerization as a biological machine]-
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