Ring coupler moving via the 'forced walk' mechanism [Microtubule depolymerization as a biological machine]

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorEfremov, Artem-
Autor(es): dc.creatorGrishchuk, Ekaterina L.-
Autor(es): dc.creatorMcIntosh, J. Richard-
Autor(es): dc.creatorAtaullakhanov, Fazly I.-
Data de aceite: dc.date.accessioned2019-08-21T18:25:47Z-
Data de disponibilização: dc.date.available2019-08-21T18:25:47Z-
Data de envio: dc.date.issued2016-10-26-
Data de envio: dc.date.issued2016-10-26-
Fonte completa do material: dc.identifierhttp://acervodigital.unesp.br/handle/unesp/365469-
Fonte completa do material: dc.identifierhttp://objetoseducacionais2.mec.gov.br/handle/mec/23026-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/471675-
Descrição: dc.descriptionThis video shows the microtubule-depolymerization dependent motions of a ring coupler. Although the plane of the ring oscillates slightly, it remains motionlessly on the microtubule wall until the shortening end comes by (thermal energy is not sufficient to cause Brownian 'random walks' with any appreciable frequency). Bending protofilaments, however, can push on the linkers, forcing the ring to walk in front of the protofilaments' flare. This directed motion is highly deterministic, but the exact pathway of the ring's transitions between successive minimum energy configurations is stochastic and varies in repeated calculations. A strongly bound ring retards the rate with which the protofilaments bend, so it slows the rate of microtubule shortening. Furthermore, such tight binding reduces the useful work that can be performed by the microtubule, e.g. in moving a cargo, but it ensures a stable ring's attachment to the microtubule end, even if the flared protofilaments shorten or the microtubule begins to polymerize. It has been therefore suggested that a reasonable compromise between a reduced efficiency of force transduction and an increased strength of attachment might be appropriate for the coupler in an organism like S. cerevisiae, where a kinetochore is stably attached to only one microtubule and the chromosomes do not move far during Anaphase A-
Descrição: dc.descriptionComponente Curricular::Educação Superior::Ciências Biológicas::Morfologia-
Publicador: dc.publisherThe American Society for Cell Biology, ASCB Image & Video Library-
Relação: dc.relationVideo 3. Ring video 3 - Coupler Moving via the 'Forced Walk' Mechanism.mov-
Direitos: dc.rightsYou may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes-
Palavras-chave: dc.subjectCell-
Palavras-chave: dc.subjectDepolymerization-
Palavras-chave: dc.subjectBrownian motion-
Palavras-chave: dc.subjectEducação Superior::Ciências Biológicas::Morfologia::Citologia e Biologia Celular-
Título: dc.titleRing coupler moving via the 'forced walk' mechanism [Microtubule depolymerization as a biological machine]-
Tipo de arquivo: dc.typetexto-
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