Model of the tomogram

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarsh, Brad J.-
Autor(es): dc.creatorHowell, Kathryn E.-
Autor(es): dc.creatorMcIntosh, J. Richard-
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Descrição: dc.descriptionAll of the organelles and structures within the tomogram shown in the Dual Axis 3-D Reconstructions movie (6c) were individually traced and modeled with tools in the IMOD software package. Each structure was considered as a separate object and was modeled in a different color. The finished model demonstrates the 3-D complexity of the Golgi and its position in the cytoplasm relative to other organelles and elements of the cytoskeleton. The seven cisternae of the Golgi Complex (named C1-C7 in the cis-to-trans direction) are colored light blue (C1), pink (C2), rose (C3), green (C4), dark blue (C5), amber (C6) and red (C7). When the model is broken down to display subsets of the Golgi cisternae, one can see that they vary considerably in size and that many are reticular. The extent to which adjacent cisternae adhere to one another varies as well. For example, C6 has pulled away slightly from C5 and is extremely reticular. Also, a large tubule extends from C6 to a region distal to the Golgi stack. None of the vesicles or tubules on C6 are clathrin coated. The trans-most cisterna (C7) differs from the previous six cisternae in that it is more 'solid' (less reticular) and all vesicles and tubules budding from it are coated with clathrin. This point is shown more clearly in tomogram 6e, where the C6 and C7 cisternae are isolated-
Descrição: dc.descriptionComponente Curricular::Educação Superior::Ciências Biológicas::Morfologia-
Publicador: dc.publisherThe American Society for Cell Biology, ASBC Image & Video Library-
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Direitos: dc.rightsYou may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes-
Palavras-chave: dc.subjectGolgi complex-
Palavras-chave: dc.subjectSecretory pathway-
Palavras-chave: dc.subjectOrganelle-
Palavras-chave: dc.subjectCisterna-
Palavras-chave: dc.subjectEducação Superior::Ciências Biológicas::Morfologia::Citologia e Biologia Celular-
Título: dc.titleModel of the tomogram-
Aparece nas coleções:Repositório Institucional - Acervo Digital Unesp

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