Formation and stability of green and low-cost magnetoliposomes of the soy lecithin, stigmasterol, and β-sitosterol for hyperthermia treatments.

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Autor(es): dc.creatorSilva, Rosangela Maria Ferreira da Costa e-
Autor(es): dc.creatorAndrade, Ângela Leão-
Autor(es): dc.creatorFreitas, Erico Tadeu Fraga-
Autor(es): dc.creatorValverde, Thalita Marcolan-
Autor(es): dc.creatorLara, Luciano Roni Silva-
Autor(es): dc.creatorMartins, Darliane Aparecida-
Autor(es): dc.creatorLopez, Jorge Luis-
Autor(es): dc.creatorStumpf, Humberto Osório-
Autor(es): dc.creatorNascentes, Clésia Cristina-
Autor(es): dc.creatorGoes, Alfredo Miranda de-
Autor(es): dc.creatorDomingues, Rosana Zacarias-
Data de aceite: dc.date.accessioned2026-08-11T11:24:07Z-
Data de disponibilização: dc.date.available2026-08-11T11:24:07Z-
Data de envio: dc.date.issued2025-12-10-
Data de envio: dc.date.issued2024-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/21144-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-024-82480-x-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1187935-
Descrição: dc.descriptionMagnetoliposomes containing magnetite, soy lecithin, stigmasterol, and beta-sitosterol of the mean size minor than 160 nm were obtained by a scalable and green process using autoclave and sonication without organic solvents. The formation, size of the liposome, linkage, and encapsulation of the magnetite were evaluated by Cryo-TEM. The stability of magnetoliposomes after storage for 6 months at 4 °C was improved by liposome size, the ability of soy lecithin to preserve the magnetite phase against oxidation, pH, polydispersity index, and zeta potential. The iron oxide phase stability was assessed using no conventional X-ray diffraction (high-resolution transmission electron microscopy), energy loss electron spectroscopy, and selected area electron diffraction) in time zero (fresh sample) and 6 months. The high zeta potential measured for magnetoliposomes, │53│ mV, indicated a low tendency to agglomerate. Lip-Fe3O4@lecithin with concentrations of 0.58 mg mL−1 of liposome showed high cell viability and are potential candidates for drug delivery and hyperthermia treatments in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectMagnetite stability-
Palavras-chave: dc.subjectSoy lecithin liposome-
Palavras-chave: dc.subjectSelected Area Electron Diffraction-
Título: dc.titleFormation and stability of green and low-cost magnetoliposomes of the soy lecithin, stigmasterol, and β-sitosterol for hyperthermia treatments.-
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