Effects of combined gamma aminobutyric acid supplementation and exercise training on the body composition of women : a randomized double-blind trial.

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Autor(es): dc.creatorPires, Larissa Vitalina de Medeiros-
Autor(es): dc.creatorMartins, Adilson de Barros-
Autor(es): dc.creatorTrindade, Cristina Maria de Oliveira-
Autor(es): dc.creatorBaleeiro, Raianne dos Santos-
Autor(es): dc.creatorPeixoto, Thainá Gomes-
Autor(es): dc.creatorSilva, Vitoria Louise Teixeira e-
Autor(es): dc.creatorPinto, Kelerson Mauro de Castro-
Autor(es): dc.creatorSilva, Fernanda Guimaraes Drummond e-
Autor(es): dc.creatorCoelho, Daniel Barbosa-
Autor(es): dc.creatorOliveira, Emerson Cruz de-
Autor(es): dc.creatorBecker, Lenice Kappes-
Data de aceite: dc.date.accessioned2026-08-11T11:23:59Z-
Data de disponibilização: dc.date.available2026-08-11T11:23:59Z-
Data de envio: dc.date.issued2025-12-01-
Data de envio: dc.date.issued2024-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/21122-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2405457725003018-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.clnesp.2025.04.028-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1187894-
Descrição: dc.descriptionPreclinical and clinical investigations have revealed the metabolic health benefits of gamma-aminobutyric acid (GABA) supplementation. Exercise training is widely acknowledged for its positive effects on the health of individuals with obesity. Objective: To investigate the effects of combined GABA supplementation and exercise training on the body composition, nutritional intake, physical performance, and serum biomarkers of women with obesity. Methods: Twenty-six women with obesity were investigated in this randomized, double-blind, placebo controlled trial. They received daily GABA (200 mg) supplementation for 90 days alongside exercise training (3 days/week). Results: For intragroup comparisons hand grip improved in both groups (placebo, p ¼ 0.00276; GABA, p ¼ 0.00012), while sit-up performance increased only in the GABA group (p ¼ 0.00664). Body mass index (p ¼ 0.01273) and waist circumference (p ¼ 0.01393) decreased in the GABA group. In the placebo group, body mass (p ¼ 0.02956), fat-free mass (p ¼ 0.00344), and basal metabolic rate (BMR) (p ¼ 0.00386) decreased, while body fat increased (p ¼ 0.02666). There were no differences in daily macronutrient intake, BMR, body mass, body fat, fat mass, fat-free mass, hip circumference, waist-hip ratio, blood pressure, heart rate, or serum levels of glucose, triglycerides, leptin, resistin, chemokine (CeC motif) ligand 2, chemokine ligand 16, and growth hormone between groups. Conclusion: GABA supplementation combined with exercise training enhanced physical performance, accompanied by modest improvements in body composition, with no adverse effects on nutritional, physiological, or blood serum parameters.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBody composition-
Palavras-chave: dc.subjectDietary supplements-
Palavras-chave: dc.subjectGamma aminobutyric acid-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectObesity-
Título: dc.titleEffects of combined gamma aminobutyric acid supplementation and exercise training on the body composition of women : a randomized double-blind trial.-
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