Curcumin prevents renal damage of L‐NAME induced hypertension in by reducing MMP‐2 and MMP‐9.

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Autor(es): dc.creatorPereira, Bruna Pinheiro-
Autor(es): dc.creatorSilva, Alessandra Oliveira-
Autor(es): dc.creatorAwata, Wanessa Mayumi Carvalho-
Autor(es): dc.creatorPimenta, Gustavo Félix-
Autor(es): dc.creatorRibeiro, Jéssyca Milene-
Autor(es): dc.creatorAlmeida, Carolina Aparecida de Faria-
Autor(es): dc.creatorAntonietto, Carla Renata Kitanishi-
Autor(es): dc.creatorReis, Luis Felipe Cunha dos-
Autor(es): dc.creatorEsteves, Alessandra-
Autor(es): dc.creatorTorres, Larissa Helena Lobo-
Autor(es): dc.creatorPaula, Fernanda Borges de Araújo-
Autor(es): dc.creatorRuginsk, Sílvia Graciela-
Autor(es): dc.creatorTirapelli, Carlos Renato-
Autor(es): dc.creatorRizzi, Ellen-
Autor(es): dc.creatorCeron, Carla Speroni-
Data de aceite: dc.date.accessioned2026-08-11T11:23:39Z-
Data de disponibilização: dc.date.available2026-08-11T11:23:39Z-
Data de envio: dc.date.issued2025-11-16-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/21024-
Fonte completa do material: dc.identifierhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.4119-
Fonte completa do material: dc.identifierhttps://doi.org/10.1002/cbf.4119-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1187809-
Descrição: dc.descriptionIn the present study, we investigated whether curcumin administration would interfere with the main renal features of l-NAME-induced hypertension model. For this purpose, we conducted both in vitro and in vivo experiments to evaluate renal indicators of inflammation, oxidative stress, and metalloproteinases (MMPs) expression/activity. Hypertension was induced by l-NAME (70 mg/kg/day), and Wistar rats from both control and hypertensive groups were treated with curcumin (50 or 100 mg/kg/day; gavage) or vehicle for 14 days. Blood and kidneys were collected to determine serum creatinine levels, histological alterations, oxidative stress, MMPs expression and activity, and ED1 expression. l-NAME increased blood pressure, but both doses of curcumin treatment reduced these values. l-NAME treatment increased creatinine levels, glomeruli area, Bowman's space, kidney MMP-2 activity, as well as MMP-9 and ED1 expression, and reduced the number of glomeruli. Curcumin treatment prevented the increase in creatinine levels, MMP-2 activity, and reduced MMP-2, MMP-9, ED1, and superoxide levels, as well as increased superoxide dismutase activity and partially prevented glomeruli alterations. Moreover, curcumin directly inhibited MMP-2 activity in vitro. Thus, our main findings demonstrate that curcumin reduced l-NAME-induced hypertension and renal glomerular alterations, inhibited MMP-2 and MMP-9 expression/activity, and reduced oxidative stress and inflammatory processes, which may indirectly impact hypertension-induced renal outcomes.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectKidney damage-
Palavras-chave: dc.subjectL‐NAME induced hypertension-
Palavras-chave: dc.subjectMatrix metalloproteinases-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleCurcumin prevents renal damage of L‐NAME induced hypertension in by reducing MMP‐2 and MMP‐9.-
Aparece nas coleções:Repositório Institucional - UFOP

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