Exploring the interaction between vitamin D pathway gene polymorphisms, vitamin D status, and depression : a population-based study.

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Autor(es): dc.creatorSabião, Thaís da Silva-
Autor(es): dc.creatorMenezes Júnior, Luiz Antônio Alves de-
Autor(es): dc.creatorBatista, Aline Priscila-
Autor(es): dc.creatorMoura, Samara Silva de-
Autor(es): dc.creatorMeireles, Adriana Lúcia-
Autor(es): dc.creatorMenezes, Mariana Carvalho de-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorCarraro, Júlia Cristina Cardoso-
Data de aceite: dc.date.accessioned2026-08-11T11:22:14Z-
Data de disponibilização: dc.date.available2026-08-11T11:22:14Z-
Data de envio: dc.date.issued2025-12-11-
Data de envio: dc.date.issued2024-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/21175-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0899900725001200-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.nut.2025.112802-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1187440-
Descrição: dc.descriptionBackground: The association between vitamin D and depression is controversial, mainly because of genetic differences and confounding factors. Objective: To evaluate the association between vitamin D and depressive symptoms, considering the influence of genetic variations, skin color, and lifestyle. Methods: This population-based cross-sectional study was conducted during the COVID-19 pandemic. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Vitamin D deficiency was defined as levels of <20 ng/mL in healthy individuals or <30 ng/mL in at-risk groups. A genetic risk score for vitamin D deficiency was developed based on gene polymorphisms involved in vitamin D metabolism (DHCR7, GC, and VDR), and this score was categorized into tertiles. Results: Among 1637 participants, 50.9% were women, with a mean age of 42.9 years (95% CI: 41.62-44.26). No association was found between vitamin D deficiency and depressive symptoms. However, the interaction analysis between vitamin D deficiency and the genetic risk score in the subgroups revealed disparities. Individuals with non-white skin color and vitamin D deficiency in the third tertile, supplement non-users with vitamin D deficiency in the second and third tertiles, and participants with insufficient sun exposure and vitamin D deficiency in the second and third tertiles had a higher prevalence of depressive symptoms. Conclusion: Vitamin D deficiency is linked to a higher prevalence of depressive symptoms in genetically predisposed Brazilians with non-white skin, no vitamin D supplementation, and insufficient sun exposure. Mental health guidelines should aim to promote lifestyle modifications among individuals who are predisposed to depressive symptoms.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPolymorphism-
Palavras-chave: dc.subjectPopulation-based study-
Palavras-chave: dc.subjectSkin color-
Palavras-chave: dc.subjectSun exposure-
Palavras-chave: dc.subjectVitamin D-
Título: dc.titleExploring the interaction between vitamin D pathway gene polymorphisms, vitamin D status, and depression : a population-based study.-
Aparece nas coleções:Repositório Institucional - UFOP

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