Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

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Autor(es): dc.creatorLong, Quan-Xin-
Autor(es): dc.creatorTang, Xiao-Jun-
Autor(es): dc.creatorShi, Qiu-Lin-
Autor(es): dc.creatorLi, Qin-
Autor(es): dc.creatorDeng, Hai-Jun-
Autor(es): dc.creatorYuan, Jun-
Autor(es): dc.creatorHu, Jie-Li-
Autor(es): dc.creatorXu, Wei-
Autor(es): dc.creatorZhang, Yong-
Autor(es): dc.creatorLv, Fa-Jin-
Autor(es): dc.creatorSu, Kun-
Autor(es): dc.creatorZhang, Fan-
Autor(es): dc.creatorGong, Jiang-
Autor(es): dc.creatorWu, Bo-
Autor(es): dc.creatorLiu, Xia-Mao-
Autor(es): dc.creatorLi, Jin-Jing-
Autor(es): dc.creatorQiu, Jing-Fu-
Autor(es): dc.creatorChen, Juan-
Autor(es): dc.creatorHuang, Ai-Long-
Data de aceite: dc.date.accessioned2026-02-09T12:55:05Z-
Data de disponibilização: dc.date.available2026-02-09T12:55:05Z-
Data de envio: dc.date.issued2020-06-22-
Data de envio: dc.date.issued2020-06-22-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41519-
Fonte completa do material: dc.identifierhttps://www.nature.com/articles/s41591-020-0965-6-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1170877-
Descrição: dc.descriptionThe clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People’s Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15–26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6–10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8–38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.-
Idioma: dc.languageen-
Publicador: dc.publisherNature Publishing Group-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceNature Medicine-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Título: dc.titleClinical and immunological assessment of asymptomatic SARS-CoV-2 infections-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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