L-Arginine pretreatment reduces intestinal mucositis as induced by 5-FU in mice

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLeocádio, Paola C. L.-
Autor(es): dc.creatorAntunes, Maísa M.-
Autor(es): dc.creatorTeixeira, Lílian G.-
Autor(es): dc.creatorLeonel, Alda J.-
Autor(es): dc.creatorAlvarez-Leite, Jacqueline I.-
Autor(es): dc.creatorMachado, Denise C. C.-
Autor(es): dc.creatorGeneroso, Simone V.-
Autor(es): dc.creatorCardoso, Valbert N.-
Autor(es): dc.creatorCorreia, Maria Isabel T. D.-
Data de aceite: dc.date.accessioned2026-02-09T12:52:43Z-
Data de disponibilização: dc.date.available2026-02-09T12:52:43Z-
Data de envio: dc.date.issued2020-02-05-
Data de envio: dc.date.issued2020-02-05-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/38918-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.1080/01635581.2015.1004730?journalCode=hnuc20-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1170056-
Descrição: dc.descriptionBeneficial effects of L-arginine on immune responses and bowel function have been reported. Mucositis is a side effect of chemotherapy treatment that affects approximately 40% of patients. This complication is characterized by inflammation that affects the gastrointestinal tract, increasing permeability and causing abdominal pain, nausea, vomiting, and diarrhea, which worsen the patient's nutritional status and increases morbimortality. The aim of this study was to evaluate the effect of pretreating with 2% L-arginine supplementation in water on mucositis as induced by 5-fluorouracil (5-FU; a single dose of 200 mg/kg body weight) in Swiss male mice. The effect of L-arginine on weight, intestinal permeability, morphology, and the histopathological score of the small intestine (from 0 to 12), oxidative stress, myeloperoxidase (MPO), and N-acetylglucosaminidase (NAG) activities were evaluated. Intestinal length improvement was observed, in addition to the partial recovery of the mucosal architecture. L-arginine attenuated the histopathological score and MPO activity. There was also an improvement in intestinal permeability, despite weight loss after 5-FU administration. In conclusion, L-arginine can positively impact intestinal mucositis by promoting partial mucosal recovery, reducing inflammation and improving intestinal permeability.-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceNutrition and Cancer-
Palavras-chave: dc.subjectIntestinal mucositis-
Palavras-chave: dc.subjectGastrointestinal inflammation-
Palavras-chave: dc.subjectMucosite intestinal-
Palavras-chave: dc.subjectInflamação gastrointestinal-
Título: dc.titleL-Arginine pretreatment reduces intestinal mucositis as induced by 5-FU in mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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