Gold-coated superparamagnetic iron oxide nanoparticles attenuate collagen-induced arthritis after magnetic targeting

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarneiro, Maria Fernanda Hornos-
Autor(es): dc.creatorMachado, Ana Rita T.-
Autor(es): dc.creatorAntunes, Lusânia M. G.-
Autor(es): dc.creatorSouza, Talita E.-
Autor(es): dc.creatorFreitas, Victor A.-
Autor(es): dc.creatorOliveira, Luiz C. A.-
Autor(es): dc.creatorRodrigues, Jairo L.-
Autor(es): dc.creatorPereira, Márcio C.-
Autor(es): dc.creatorBarbosa Júnior, Fernando-
Data de aceite: dc.date.accessioned2026-02-09T12:52:33Z-
Data de disponibilização: dc.date.available2026-02-09T12:52:33Z-
Data de envio: dc.date.issued2020-05-06-
Data de envio: dc.date.issued2020-05-06-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40619-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s12011-019-01799-z-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1170000-
Descrição: dc.descriptionThe aim of the study was to evaluate if gold-coated superparamagnetic iron oxide nanoparticles (AuSPION) magnetic-targeted to the arthritic articulation of collagen induced arthritis (CIA) rats are able to ameliorate rheumatoid arthritis without producing significant biological adverse effects in comparison to colloidal Au nanoparticles (AuC) and metotrexate (MTX). Male Wistar rats were divided into control; arthritic; AuSPION (150 μg kg−1); AuC (150 μg kg−1) and MTX (2.5 μg kg−1). Treatments were administered thrice every other day by the intraperitoneal route 15 min after all groups had a neodymium magnet coupled to the right ankle joint (kept for 1 h). Paw edema and body weight were measured weekly. Joint sections were evaluated by Haematoxylin & Eosin and immunohistochemistry (TNF-α, IL-1β). Biomarkers of oxidative stress were used to evaluate toxicity. Among the evaluated treatments, AuSPION led to significant clinical improvements (decreased edema and infiltration by leukocytes as well as less positively immunostained cells for both TNF-α and IL-1β in synovium) accompanied by a lack of toxicity as indicated by redox state and genotoxicity assays. Our results clearly indicate that the magnetic targeting of AuSPION suppresses joint edema and inflammation, cytokine expression as well as the redox imbalance, thereby contributing to an amelioration of arthritis severity in CIA rats. The results demonstrate for the first time the potentiality of AuSPION administration under a magnetic field as an attractive alternative for future treatments of rheumatic diseases.-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceBiological Trace Element Research-
Título: dc.titleGold-coated superparamagnetic iron oxide nanoparticles attenuate collagen-induced arthritis after magnetic targeting-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.