Human challenge studies to accelerate coronavirus vaccine licensure

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorEyal, Nir-
Autor(es): dc.creatorLipsitch, Marc-
Autor(es): dc.creatorSmith, Peter G.-
Data de aceite: dc.date.accessioned2026-02-09T12:52:04Z-
Data de disponibilização: dc.date.available2026-02-09T12:52:04Z-
Data de envio: dc.date.issued2020-04-24-
Data de envio: dc.date.issued2020-04-24-
Data de envio: dc.date.issued2020-03-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40302-
Fonte completa do material: dc.identifierhttps://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa152/5814216-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1169836-
Descrição: dc.descriptionControlled human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the testing and potential rollout of efficacious vaccines. By replacing conventional phase 3 testing of vaccine candidates, such trials may subtract many months from the licensure process, making efficacious vaccines available more quickly. Obviously, challenging volunteers with this live virus risks inducing severe disease and possibly even death. However, we argue that such studies, by accelerating vaccine evaluation, could reduce the global burden of coronavirus-related mortality and morbidity. Volunteers in such studies could autonomously authorize the risks to themselves, and their net risk could be acceptable if participants comprise healthy young adults, who are at relatively low risk of serious disease following natural infection, if they have a high baseline risk of natural infection, and if during the trial they receive frequent monitoring and, following any infection, the best available care.-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Academic-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceThe Journal of Infectious Diseases-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectVaccines-
Palavras-chave: dc.subjectHuman challenge studies-
Palavras-chave: dc.subjectRandomized controlled trials-
Palavras-chave: dc.subjectRisk-taking-
Palavras-chave: dc.subjectEthics-
Título: dc.titleHuman challenge studies to accelerate coronavirus vaccine licensure-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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