Epidemiology of COVID-19 infection in young children under five years: a systematic review and meta-analysis

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Autor(es): dc.creatorUddin Bhuiyan, Mejbah-
Autor(es): dc.creatorStiboy, Eunice-
Autor(es): dc.creatorHassan, Zakiul-
Autor(es): dc.creatorChan, Mei-
Autor(es): dc.creatorIslam, Saiful-
Autor(es): dc.creatorHaider, Najmul-
Autor(es): dc.creatorJaffe, Adam-
Autor(es): dc.creatorHomaira, Nusrat-
Data de aceite: dc.date.accessioned2026-02-09T12:50:02Z-
Data de disponibilização: dc.date.available2026-02-09T12:50:02Z-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2020-12-10-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45853-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0264410X2031570X#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1169156-
Descrição: dc.descriptionIntroduction Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-risk age-group for respiratory infection, remain unclear. We conducted a systematic review and meta-analysis of epidemiological and clinical characteristics of COVID-19 infection in children under five years. Method Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, we searched several electronic databases (Pubmed, EMBASE, Web of Science, and Scopus) with no language restriction for published epidemiological studies and case-reports reporting laboratory-confirmed COVID-19 infection in children under five years until June 4, 2020. We assessed pooled prevalence for key demographics and clinical characteristics using Freeman-Tukey double arcsine random-effects model for studies except case-reports. We evaluated risk of bias separately for case-reports and other studies. Results We identified 1,964 articles, of which, 65 articles were eligible for systematic review that represented 1,214 children younger than five years with laboratory-confirmed COVID-19 infection. The pooled estimates showed that 50% young COVID-19 cases were infants (95% CI: 36% - 63%, 27 studies); 53% were male (95% CI: 41% - 65%, 24 studies); 43% were asymptomatic (95% CI: 15% - 73%, 9 studies) and 7% (95% CI: 0% - 30%, 5 studies) had severe disease that required intensive-care-unit admission. Of 139 newborns from COVID-19 infected mothers, five (3.6%) were COVID-19 positive. There was only one death recorded. Discussion This systematic review reports the largest number of children younger than five years with COVID-19 infection till date. Our meta-analysis shows nearly half of young COVID-19 cases were asymptomatic and half were infants, highlighting the need for ongoing surveillance to better understand the epidemiology, clinical pattern, and transmission of COVID-19 to develop effective preventive strategies against COVID-19 disease in young paediatric population-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceVaccine-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCOVID-19 newborns-
Título: dc.titleEpidemiology of COVID-19 infection in young children under five years: a systematic review and meta-analysis-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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