Relationship between environmental factors and gray matter atrophy in refractory MTLE

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorYasuda, C.L.-
Autor(es): dc.creatorMorita, M.E.-
Autor(es): dc.creatorAlessio, A.-
Autor(es): dc.creatorPereira, A.R.-
Autor(es): dc.creatorBalthazar, M.L.F.-
Autor(es): dc.creatorSaúde, André Vital-
Autor(es): dc.creatorCosta, A.L.F.-
Autor(es): dc.creatorCosta, A.L.C.-
Autor(es): dc.creatorCardoso, T.A.-
Autor(es): dc.creatorBetting, L.E.-
Autor(es): dc.creatorGuerreiro, C.A.M.-
Autor(es): dc.creatorDamasceno, B.P.-
Autor(es): dc.creatorLopes-Cendes, I.-
Autor(es): dc.creatorTedeschi, H.-
Autor(es): dc.creatorOliveira, E. de-
Autor(es): dc.creatorCendes, F.-
Data de aceite: dc.date.accessioned2026-02-09T12:49:44Z-
Data de disponibilização: dc.date.available2026-02-09T12:49:44Z-
Data de envio: dc.date.issued2017-02-16-
Data de envio: dc.date.issued2017-02-16-
Data de envio: dc.date.issued2010-03-30-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/12281-
Fonte completa do material: dc.identifierhttp://www.neurology.org/content/74/13/1062.short-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1169061-
Descrição: dc.descriptionObjective: To investigate clinical, neuropsychological, and MRI abnormalities (gray matter atrophy [GMA] and white matter atrophy [WMA]) in surgical mesial temporal lobe epilepsy (MTLE) patients with and without familial antecedent for epilepsy. Methods: A cohort study including 69 operated patients with unilateral MTLE, divided into a group of 29 patients (mean age 35.8 ± 10.4 years) with a negative family history (FH) of epilepsy and a group of 40 patients (32.8 ± 10 years) with a positive FH. We performed voxel-based morphometry (VBM) on preoperative MRIs and investigated possible clinical and neuropsychological differences between the 2 groups. We also performed VBM and t tests to compare the patients' groups with normal controls. Results: The negative-FH group had lower IQ scores (p = 0.004), performed poorer on the Boston Naming Test (p = 0.02) and on delayed recall (p = 0.03), and presented a more prominent asymmetry index of hippocampal volume (p = 0.04) and more frequent initial precipitating injuries (p = 0.023). VBM showed a more restricted pattern of GMA in the positive-FH group and a more bilateral and widespread pattern of GMA in the negative-FH group, involving thalami, temporal, frontal, parietal, and occipital lobes. WMA was widespread and bilateral in both groups. Conclusions: The more widespread structural voxel-based morphometry abnormalities and worse IQ performance identified in the negative–family history (FH) group may result from a stronger environmental influence, including initial precipitating injuries. This is further support for the hypothesis that hippocampal sclerosis in mesial temporal lobe epilepsy with positive FH is determined by a stronger genetic predisposition with less influence of environmental factors compared with patients in the negative-FH group.-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Academy of Neurology-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceNeurology-
Palavras-chave: dc.subjectEpilepsy – Complications-
Palavras-chave: dc.subjectWhite matter – Atrophy-
Palavras-chave: dc.subjectGray matter – Atrophy-
Palavras-chave: dc.subjectVoxel-based morphometry (VBM)-
Palavras-chave: dc.subjectEpilepsia – Complicações-
Palavras-chave: dc.subjectSubstância branca – Atrofia-
Palavras-chave: dc.subjectSubstância cinzenta – Atrofia-
Palavras-chave: dc.subjectMorfometria baseada em voxel-
Título: dc.titleRelationship between environmental factors and gray matter atrophy in refractory MTLE-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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