Peroxisome proliferator-activated receptor delta-PPARδ agonist (L-165041) enhances bovine embryo survival and post vitrification viability

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Autor(es): dc.creatorSánchez Viafara, Jesús Alfonso-
Autor(es): dc.creatorVasconcelos, Gisvani Lopes de-
Autor(es): dc.creatorMaculan, Renata-
Autor(es): dc.creatorAlves, Nadja Gomes-
Autor(es): dc.creatorFerreira, Marcos Brandao Dias-
Autor(es): dc.creatorSudano, Mateus José-
Autor(es): dc.creatorMingoti, Gisele Zoccal-
Autor(es): dc.creatorNunes, Giovana Barros-
Autor(es): dc.creatorLima, Renato Ribeiro de-
Autor(es): dc.creatorDrumond, Roberti Martins-
Autor(es): dc.creatorSantos, Raphael Nunes dos-
Autor(es): dc.creatorEberlin, Marcos Nogueira-
Autor(es): dc.creatorNegrão, Fernanda-
Autor(es): dc.creatorJasmin-
Autor(es): dc.creatorDonato, Mariana Aragão M.-
Autor(es): dc.creatorPeixoto, Christina A.-
Autor(es): dc.creatorSouza, José Camisão de-
Data de aceite: dc.date.accessioned2026-02-09T12:48:23Z-
Data de disponibilização: dc.date.available2026-02-09T12:48:23Z-
Data de envio: dc.date.issued2022-08-19-
Data de envio: dc.date.issued2022-08-19-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/53339-
Fonte completa do material: dc.identifierhttps://doi.org/10.1071/RD21245-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1168630-
Descrição: dc.descriptionThe effect of L-165041 (PPARδ-agonist) on decreasing apoptosis and intracellular lipid content was assessed in fresh and vitrified–warmed in vitro-produced bovine embryos. It was hypothesised that the addition of L-165041 to the culture medium enhances development and cryopreservation. Oocytes were allocated to one of two treatments: control-standard culture medium, or L-165041 added to the medium on day 1 with no media change. Ultrastructure, cleavage, and blastocyst rates were evaluated in fresh, and in post-vitrification cultured embryos by optical and electronic microscopy. A subset of fresh embryos were fixed for TUNEL assay and for Sudan-Black-B histochemical staining. Vitrified–warmed embryos were assessed using MALDI-MS technique. Cleavage and blastocyst rates (control 49.4 ± 5.2, L-165041 51.8 ± 4.3) were not influenced by L-165041. The proportion of inner cell mass cells (ICM) was higher in fresh embryos, and the rate of total and ICM apoptosis was lower in L-165041. In warmed-embryos, total and ICM apoptosis was lower in L-165041. The overall hatching rate was higher in L-165041 (66.62 ± 2.83% vs 53.19 ± 2.90%). There was less lipid accumulation in fresh L-165041-embryos. In conclusion, the use of L-165041 is recommended to improve the viability of in vitro-derived bovine embryos.-
Idioma: dc.languageen-
Publicador: dc.publisherCSIRO Publishing-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceReproduction, Fertility and Development-
Palavras-chave: dc.subjectBovine embryo - Cryopreservation-
Palavras-chave: dc.subjectCulture medium-
Palavras-chave: dc.subjectEmbryo apoptosis-
Palavras-chave: dc.subjectVitrification-
Palavras-chave: dc.subjectEmbriões bovinos - Criopreservação-
Palavras-chave: dc.subjectMeio de cultura-
Palavras-chave: dc.subjectApoptose do embrião-
Palavras-chave: dc.subjectVitrificação-
Título: dc.titlePeroxisome proliferator-activated receptor delta-PPARδ agonist (L-165041) enhances bovine embryo survival and post vitrification viability-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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