Anti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMoreira, Lucimara Q.-
Autor(es): dc.creatorVilela, Fabiana C.-
Autor(es): dc.creatorOrlandi, Lidiane-
Autor(es): dc.creatorDias, Danielle F.-
Autor(es): dc.creatorSantos, Ana Laura A.-
Autor(es): dc.creatorSilva, Marcelo A. da-
Autor(es): dc.creatorPaiva, Renato-
Autor(es): dc.creatorAlves-da-Silva, Geraldo-
Autor(es): dc.creatorGiusti-Paiva, Alexandre-
Data de aceite: dc.date.accessioned2026-02-09T12:44:24Z-
Data de disponibilização: dc.date.available2026-02-09T12:44:24Z-
Data de envio: dc.date.issued2020-02-04-
Data de envio: dc.date.issued2020-02-04-
Data de envio: dc.date.issued2011-11-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/38858-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0378874111007331-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1167320-
Descrição: dc.descriptionAim of the study: Byrsonima intermedia is commonly used for its antiseptic, antimicrobial, and anti-inflammatory properties in the treatment of diarrhea and dysentery in Brazilian folk medicine. The purpose of this study was to examine the anti-inflammatory activity of the aqueous extract and fractions of Byrsonima intermedia leaves. Materials and methods: rats with carrageenan-induced paw edema and fibrovascular tissue growth, which was induced by subcutaneous implantation of a cotton pellet, were used as acute and chronic animal models of inflammation to investigate the anti-inflammatory effects of the aqueous extract and the individual ethyl acetate (EtOAc) and aqueous fractions of Byrsonima intermedia and catechin. High-performance liquid chromatography (HPLC) was used to determine the fingerprint chromatogram of the aqueous extract and fractions of Byrsonima intermedia. Results: the crude aqueous extract at test doses of 30–300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reducing carrageenan-induced paw edema, as did the ethyl acetate (100 mg/kg) and aqueous fractions (30–100 mg/kg). In the chronic inflammation rat animal model with fibrovascular tissue growth, the aqueous extract of Byrsonima intermedia (BiAE) at doses of 30–300 mg/kg and the individual EtOAc and aqueous fractions at doses of 30–100 mg/kg and catechin significantly reduced the formation of granulomatous tissue. The presence of catechin and phenolic compounds in the extract and fractions of Byrsonima intermedia was confirmed using HPLC. Conclusion: BiAE and the individual EtOAc and aqueous fractions of Byrsonima intermedia exhibited chronic and acute anti-inflammatory efficacy in rats, which supports previous claims of its use in traditional medicine.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Ethnopharmacology-
Palavras-chave: dc.subjectAnti-inflammatory activity-
Palavras-chave: dc.subjectByrsonima intermedia-
Palavras-chave: dc.subjectCatechin-
Palavras-chave: dc.subjectChromatographic fingerprints-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectMalphigiaceae-
Título: dc.titleAnti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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