Platinum(II) complexes with carbazates and hydrazydes: synthesis, spectral characterization, computational modeling, and biological studies

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRodrigues, M. A.-
Autor(es): dc.creatorMarzano, I. M.-
Autor(es): dc.creatorRibeiro, G. H.-
Autor(es): dc.creatorColina-Vegas, L.-
Autor(es): dc.creatorPivatto, M.-
Autor(es): dc.creatorFontes, A. P. S.-
Autor(es): dc.creatorRibeiro, C. M.-
Autor(es): dc.creatorPavan, F. R.-
Autor(es): dc.creatorAlmeida, K. J. de-
Autor(es): dc.creatorBatista, A. A.-
Autor(es): dc.creatorPereira-Maia, E. C.-
Autor(es): dc.creatorGuerra, W.-
Data de aceite: dc.date.accessioned2026-02-09T12:43:48Z-
Data de disponibilização: dc.date.available2026-02-09T12:43:48Z-
Data de envio: dc.date.issued2020-05-10-
Data de envio: dc.date.issued2020-05-10-
Data de envio: dc.date.issued2015-06-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40771-
Fonte completa do material: dc.identifierhttps://kundoc.com/pdf-platinumii-complexes-with-carbazates-and-hydrazides-synthesis-spectral-character.html#-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1167119-
Descrição: dc.descriptionThis work reports on the synthesis and characterization of complexes of the type cis[Pt(L)2X2], where L=4-methoxybenzylcarbazate (4-MC), benzyl carbazate (BC), 4-fluorophenoxyacetic acid hydrazide (4-FH), 3-methoxybenzoic acid hydrazide (3-MH), ethyl carbazate (EC), tert-butyl carbazate (TC), (4-hydroxy-phenyl)-acetic acid hydrazide (4-HH), and X = Cl– or I–. The structures of the platinum(II) complexes were optimized and theoretical data show good agreement with the experimental results, suggesting that the ligands are coordinated via the NH2 groups. The cytotoxic activity of three representative compounds was evaluated in a chronic myelogenous leukemia cell line and health cell line from mouse (L929). The platinum complex with 4-fluorophenoxyacetic acid hydrazide was more active than the free ligand and carboplatin therefore it may be considered a promising antitumor agent. In addition, the platinum complexes with 4-methoxybenzylcarbazate (4MC) and benzyl carbazate (BC) exhibited good activity. On the other hand, microbiological assays against Mycobacterium tuberculosis showed that all complexes and organic compounds are not very active.-
Idioma: dc.languageen-
Publicador: dc.publisherKundoc.com-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourcePolyhedron-
Palavras-chave: dc.subjectPlatinum complexes-
Palavras-chave: dc.subjectHydrazides-
Palavras-chave: dc.subjectCarbazate-
Palavras-chave: dc.subjectComputational modeling-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectCytotoxic activity-
Título: dc.titlePlatinum(II) complexes with carbazates and hydrazydes: synthesis, spectral characterization, computational modeling, and biological studies-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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