Genotoxic action of naphthenic acids on the fish macrophage cell line, RTS11

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorTrento, Marcus Vinicius Cardoso-
Autor(es): dc.creatorCésar, Pedro Henrique Souza-
Autor(es): dc.creatorMarcussi, Silvana-
Autor(es): dc.creatorLee, Lucy E.J.-
Data de aceite: dc.date.accessioned2026-02-09T12:43:15Z-
Data de disponibilização: dc.date.available2026-02-09T12:43:15Z-
Data de envio: dc.date.issued2019-06-13-
Data de envio: dc.date.issued2019-06-13-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/34754-
Fonte completa do material: dc.identifierhttps://www.inderscienceonline.com/doi/abs/10.1504/IJEP.2018.093045-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1166931-
Descrição: dc.descriptionNaphthenic acids (NAs) are chemical constituents found in oil sands process-affected waters (OSPW) that are distinctly toxic to biota. They comprise an ill-defined mixture of carboxylic acids implicated in endocrine disruption, acute toxicity, immunotoxicity, tissue malformation and embryotoxicity in several fish species, in addition to being cytotoxic. Recent evidence indicates a possible genotoxic effect and the present study evaluated the genotoxic potential of NAs using the 'comet' assay and the rainbow trout spleen cell line, RTS11. The results provided a genotoxic value (in arbitrary units) two times higher for the NA concentration at 10 μg/mL (≈ 105) relative to the NA at 1 μg/mL (≈ 45). NAs at 10 μg/mL gave a damage index of 45.86% compared to the damage observed with a positive control-hydrogen peroxide, which was 90.66% (evaluated at 100 μM). The data obtained suggest a genotoxic potential for NAs at doses that could occur naturally in OSPW.-
Idioma: dc.languageen-
Publicador: dc.publisherInderscience Enterprises-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Environment and Pollution-
Palavras-chave: dc.subjectEnvironmental pollution-
Palavras-chave: dc.subjectDNA fragmentation-
Palavras-chave: dc.subjectComet assay-
Palavras-chave: dc.subjectRainbow trout-
Palavras-chave: dc.subjectNaphthenic acids (NAs)-
Palavras-chave: dc.subjectRTS11 cell line-
Título: dc.titleGenotoxic action of naphthenic acids on the fish macrophage cell line, RTS11-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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