Functionalized-radiolabeled hydroxyapatite/tenorite nanoparticles as theranostic agents for osteosarcoma

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCipreste, Marcelo Fernandes-
Autor(es): dc.creatorRezende, Michele Rocha de-
Autor(es): dc.creatorHneda, Marlon Luiz-
Autor(es): dc.creatorPeres, Anderson Maia-
Autor(es): dc.creatorCotta, Alexandre Alberto Chaves-
Autor(es): dc.creatorTeixeira, Verônica de Carvalho-
Autor(es): dc.creatorMacedo, Waldemar Augusto de Almeida-
Autor(es): dc.creatorSousa, Edésia Martins Barros de-
Data de aceite: dc.date.accessioned2026-02-09T12:42:26Z-
Data de disponibilização: dc.date.available2026-02-09T12:42:26Z-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2018-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/33080-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0272884218316936-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1166666-
Descrição: dc.descriptionHydroxyapatite (HA) nanoparticles (NPs) doped with different radioisotopes for use as theranostic systems play an important role in scientific research nowadays due to their ability to simultaneously act in the treatment and diagnosis of various types of cancers. In this work, we describe the synthesis and characterization of a hydroxyapatite/tenorite nanocomposite functionalized with folic acid, representing a nanotheranostic material with potential for application as an agent in positron emission tomography imaging systems and to act specifically in the treatment and diagnosis of osteosarcoma. 64Cu and 32P were produced by nuclear activation in the TRIGA reactor at CDTN. The obtained samples were characterized by XRD with Rietveld refinement, XAFS, SEM, BET, TGA, FTIR, CHN, ICP-AES, XPS and gamma spectroscopy. We investigated how CuO grows in HA NPs, the stability of the interactions between CuO and HA constituents and the interactions between folic acid and the surface of the HA NPs. The results indicate the formation of a second phase (tenorite) besides hydroxyapatite, and that the interactions between the two phases are stable, resulting in a nanocomposite. Furthermore, the activation of 64Cu and 32P inside the HA matrix, through the exposition to a neutron flux, produces a theranostic material of interest for biological tests.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCeramics International-
Palavras-chave: dc.subjectHydroxyapatite nanoparticles-
Palavras-chave: dc.subjectTenorite nanocomposites-
Palavras-chave: dc.subjectRadiolabeled nanoparticles-
Palavras-chave: dc.subjectTheranostic systems-
Título: dc.titleFunctionalized-radiolabeled hydroxyapatite/tenorite nanoparticles as theranostic agents for osteosarcoma-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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