Leptin and leptin receptor polymorphisms, plasma leptin levels and obesity in Tunisian volunteers

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorNesrine, Zayani-
Autor(es): dc.creatorHaithem, Hamdouni-
Autor(es): dc.creatorImen, Boumaiza-
Autor(es): dc.creatorFadoua, Neffati-
Autor(es): dc.creatorAsma, Omezzine-
Autor(es): dc.creatorFadhel, Najjar Mohamed-
Autor(es): dc.creatorAli, Bouslama-
Data de aceite: dc.date.accessioned2026-02-09T12:38:58Z-
Data de disponibilização: dc.date.available2026-02-09T12:38:58Z-
Data de envio: dc.date.issued2020-04-09-
Data de envio: dc.date.issued2020-04-09-
Data de envio: dc.date.issued2018-06-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39932-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12271-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1165526-
Descrição: dc.descriptionAdipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3′UTR A/C, −2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non‐obese (body mass index [BMI] = 24.51‐3.69 kg/m2) and 160 obese (BMI = 36‐4.78 kg/m2) patients. Genotyping was performed using polymerase chain reaction‐restriction fragment length polymorphism, BMI was calculated, and Leptin level was measured by ELISA. Statistical analyses were performed by spss19.0. According to LEP 3′UTR A/C polymorphism, AC and CC genotype carriers had higher Leptin levels than AA genotype carriers, respectively, 31[0.05‐148.8] (P = .008) vs 41[0.05‐111.6] (P = .003). The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001). Concerning LEP G2548A polymorphism, our results showed that the OR of obesity associated with 2548 AA/GG was 1.87[1.106‐2.78] P = .028 vs 1.41[1.035‐1.85] P = .045 for 223AA/GG polymorphism. In our haplotype analysis, one haplotype seems to be the more protective and one other seems to be the highest risk to obesity. LEP 3′UTR A/C and LEPR K109R polymorphisms were associated with Leptin level and obesity.-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Experimental Pathology-
Palavras-chave: dc.subjectLeptin levels-
Palavras-chave: dc.subjectLEP-
Palavras-chave: dc.subjectLEPR-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectTunisian volunteers-
Título: dc.titleLeptin and leptin receptor polymorphisms, plasma leptin levels and obesity in Tunisian volunteers-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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