Altered regional blood flow distribution in Mas-deficient mice

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBotelho-Santos, Giancarla Aparecida-
Autor(es): dc.creatorBader, Michael-
Autor(es): dc.creatorAlenina, Nathalia-
Autor(es): dc.creatorSantos, Robson Augusto Souza-
Data de aceite: dc.date.accessioned2026-02-09T12:38:17Z-
Data de disponibilização: dc.date.available2026-02-09T12:38:17Z-
Data de envio: dc.date.issued2019-12-02-
Data de envio: dc.date.issued2019-12-02-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/37980-
Fonte completa do material: dc.identifierhttps://journals.sagepub.com/doi/full/10.1177/1753944712461164-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1165296-
Descrição: dc.descriptionBackground: We have recently shown that the acute infusion of angiotensin-(1–7) [Ang-(1-7)] or chronic increase in plasma Ang-(1-7) produces important changes in regional blood flow in rats. Methods: To further assess whether these changes are related to Mas, in this study hemodynamic measurements were performed in Ang-(1-7) receptor Mas knockout C57BL/6 (Mas-KO) mice and age-matched wild type (WT) control mice, using fluorescent microspheres. Results: Mean arterial pressure in urethane-anesthetized Mas-KO mice (12–16 weeks old) did not differ from that in WT mice (79 ± 2 and 80 ± 2 mmHg respectively). However, pronounced differences were observed in other hemodynamic measurements. Mas-KO mice exhibited a significant decrease in stroke volume (0.03 ± 0.01 versus 0.05 ± 0.01 ml/beat in WT) and decreased cardiac index (0.81 ± 0.08 versus 1.24 ± 0.24 ml/min/g in WT). Strikingly, Mas-KO mice exhibited a marked increase in vascular resistance and a decrease in blood flow in the kidney, lung, adrenal gland, mesentery, spleen and brown fat tissue. The decrease in blood flow ranged from 34% (spleen) to 55% (brown fat tissue). Conclusion: These results suggest that the Ang-(1-7)/Mas axis plays an important role in regional and systemic hemodynamic adjustments in mice.-
Idioma: dc.languageen-
Publicador: dc.publisherSAGE Journals-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceTherapeutic Advances in Cardiovascular Disease-
Palavras-chave: dc.subjectRenin-angiotensin system (RAS)-
Palavras-chave: dc.subjectHemodynamics-
Palavras-chave: dc.subjectBlood flow-
Palavras-chave: dc.subjectFluorescent microspheres-
Palavras-chave: dc.subjectKnockout mice-
Título: dc.titleAltered regional blood flow distribution in Mas-deficient mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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