Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS Coronavirus

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Autor(es): dc.creatorWan, Yushun-
Autor(es): dc.creatorShang, Jian-
Autor(es): dc.creatorGraham, Rachel-
Autor(es): dc.creatorBaric, Ralph S.-
Autor(es): dc.creatorLi, Fang-
Data de aceite: dc.date.accessioned2026-02-09T12:36:38Z-
Data de disponibilização: dc.date.available2026-02-09T12:36:38Z-
Data de envio: dc.date.issued2020-03-30-
Data de envio: dc.date.issued2020-03-30-
Data de envio: dc.date.issued2020-04-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39557-
Fonte completa do material: dc.identifierhttps://jvi.asm.org/content/94/7/e00127-20/article-info-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1164756-
Descrição: dc.descriptionRecently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory syndrome coronavirus (SARS-CoV). Since the SARS-CoV outbreak in 2002, extensive structural analyses have revealed key atomic-level interactions between the SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Here, we analyzed the potential receptor usage by 2019-nCoV, based on the rich knowledge about SARS-CoV and the newly released sequence of 2019-nCoV. First, the sequence of 2019-nCoV RBD, including its receptor-binding motif (RBM) that directly contacts ACE2, is similar to that of SARS-CoV, strongly suggesting that 2019- nCoV uses ACE2 as its receptor. Second, several critical residues in 2019-nCoV RBM (particularly Gln493) provide favorable interactions with human ACE2, consistent with 2019-nCoV’s capacity for human cell infection. Third, several other critical residues in 2019-nCoV RBM (particularly Asn501) are compatible with, but not ideal for, binding human ACE2, suggesting that 2019-nCoV has acquired some capacity for human-to-human transmission. Last, while phylogenetic analysis indicates a bat origin of 2019-nCoV, 2019- nCoV also potentially recognizes ACE2 from a diversity of animal species (except mice and rats), implicating these animal species as possible intermediate hosts or animal models for 2019-nCoV infections. These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019-nCoV-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Society for Microbiology-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Virology-
Palavras-chave: dc.subjectSARS coronavirus-
Palavras-chave: dc.subjectAngiotensin-converting enzyme 2 (ACE2)-
Palavras-chave: dc.subjectAnimal reservoir-
Palavras-chave: dc.subjectCross-species transmission-
Palavras-chave: dc.subjectHuman-to-human transmission-
Título: dc.titleReceptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS Coronavirus-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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