Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLin, Yong-
Autor(es): dc.creatorYuan, Jun-
Autor(es): dc.creatorLong, Quanxin-
Autor(es): dc.creatorHu, Jieli-
Autor(es): dc.creatorDeng, Haijun-
Autor(es): dc.creatorZhao, Zhenyu-
Autor(es): dc.creatorChen, Juan-
Autor(es): dc.creatorLu, Mengji-
Autor(es): dc.creatorHuang, Ailong-
Data de aceite: dc.date.accessioned2026-02-09T12:34:06Z-
Data de disponibilização: dc.date.available2026-02-09T12:34:06Z-
Data de envio: dc.date.issued2020-11-17-
Data de envio: dc.date.issued2020-11-17-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45550-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2352304220301367#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1163897-
Descrição: dc.descriptionTo date, it remains unclear if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection exacerbates liver injury in patients with chronic hepatitis B virus (HBV) infection. In this study, we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019 (COVID-19) cases, including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19. We found that there were no significant differences for the discharge rate or duration of hospitalization between the two groups. However, inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests. The enhanced liver injury induced by SARS-CoV-2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type. Moreover, the inflammatory response, including abnormal lactate dehydrogenase, D-dimer and interleukin-6 production, may contribute to this injury following SARS-CoV-2 co-infection. Collectively, SARS-CoV-2 and HBV co-infection exacerbates liver function of the patients with COVID-19.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceGenes & Diseases-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectAbnormal liver function-
Palavras-chave: dc.subjectLiver injury-
Palavras-chave: dc.subjectFunção hepática anormal-
Palavras-chave: dc.subjectLesão hepática-
Título: dc.titlePatients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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