Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphologies

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCortese, Mirko-
Autor(es): dc.creatorLee, Ji-Young-
Autor(es): dc.creatorCerikan, Berati-
Autor(es): dc.creatorNeufeldt, Christopher J.-
Autor(es): dc.creatorOorschot, Viola M. J.-
Autor(es): dc.creatorKöhrer, Sebastian-
Autor(es): dc.creatorHennies, Julian-
Autor(es): dc.creatorSchieber, Nicole L.-
Autor(es): dc.creatorRonchi, Paolo-
Autor(es): dc.creatorMizzon, Giulia-
Autor(es): dc.creatorBrey, Inés Romero-
Autor(es): dc.creatorSantarella-Mellwig, Rachel-
Autor(es): dc.creatorSchorb, Martin-
Autor(es): dc.creatorBoermel, Mandy-
Autor(es): dc.creatorMocaer, Karel-
Autor(es): dc.creatorBeckwith, Marianne S.-
Autor(es): dc.creatorTemplin, Rachel M.-
Autor(es): dc.creatorGross, Viktoriia-
Autor(es): dc.creatorPape, Constantin-
Autor(es): dc.creatorTischer, Christian-
Autor(es): dc.creatorFrankish, Jamie-
Autor(es): dc.creatorHorvat, Natalie K.-
Autor(es): dc.creatorLaketa, Vibor-
Autor(es): dc.creatorStanifer, Megan-
Autor(es): dc.creatorBoulant, Steeve-
Autor(es): dc.creatorRuggieri, Alessia-
Autor(es): dc.creatorChatel-Chaix, Laurent-
Autor(es): dc.creatorSchwab, Yannick-
Autor(es): dc.creatorSchwab, Yannick-
Data de aceite: dc.date.accessioned2026-02-09T12:31:57Z-
Data de disponibilização: dc.date.available2026-02-09T12:31:57Z-
Data de envio: dc.date.issued2020-11-17-
Data de envio: dc.date.issued2020-11-17-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45555-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S193131282030620X#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1163182-
Descrição: dc.descriptionPathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation dominated cytokine response and virus-induced cell perturbation causing cell death. Here, we employ an integrative imaging analysis to determine morphological organelle alterations induced in SARS-CoV-2 infected human lung epithelial cells. We report 3D electron microscopy reconstructions of whole-cells and subcellular compartments, revealing extensive fragmentation of the Golgi apparatus, alteration of the mitochondrial network and recruitment of peroxisomes to viral replication organelles formed by clusters of double-membrane vesicles (DMVs). These are tethered to the endoplasmic reticulum, providing insights into DMV biogenesis and spatial coordination of SARS-CoV-2 replication. Live cell imaging combined with an infection sensor reveals profound remodeling of cytoskeleton elements. Pharmacological inhibition of their dynamics suppresses SARS-CoV-2 replication. We thus report insights into virus-induced cytopathic effects, and provide alongside a comprehensive publicly available repository of 3D data-sets of SARS-CoV-2 infected cells for download and smooth online visualization.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCell Host & Microbe-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectViral replication organelles-
Palavras-chave: dc.subjectElectron tomography-
Palavras-chave: dc.subjectOrganelas de replicação viral-
Palavras-chave: dc.subjectTomografia eletrônica-
Título: dc.titleIntegrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphologies-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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