Interactions between antihyperglycemic drugs and the renin-angiotensin system: putative roles in COVID-19: a mini-review

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorNakhleh, Afif-
Autor(es): dc.creatorShehadeh, Naim-
Data de aceite: dc.date.accessioned2026-02-09T12:31:13Z-
Data de disponibilização: dc.date.available2026-02-09T12:31:13Z-
Data de envio: dc.date.issued2020-05-20-
Data de envio: dc.date.issued2020-05-20-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41114-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1871402120301053-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1162924-
Descrição: dc.descriptionBackground Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19. Methods A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications. Results The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury. Conclusions Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceDiabetes & Metabolic Syndrome: Clinical Research & Reviews-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectAngiotensin-converting enzyme 2 (ACE2)-
Palavras-chave: dc.subjectGlucose-lowering medications-
Palavras-chave: dc.subjectInsulin therapy-
Título: dc.titleInteractions between antihyperglycemic drugs and the renin-angiotensin system: putative roles in COVID-19: a mini-review-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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