Inflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes

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Autor(es): dc.creatorBonafè, Massimiliano-
Autor(es): dc.creatorPrattichizzo, Francesco-
Autor(es): dc.creatorGiuliani, Angelica-
Autor(es): dc.creatorStorci, Gianluca-
Autor(es): dc.creatorSabbatinelli, Jacopo-
Autor(es): dc.creatorOlivieri, Fabiola-
Data de aceite: dc.date.accessioned2026-02-09T12:29:31Z-
Data de disponibilização: dc.date.available2026-02-09T12:29:31Z-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41258-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1359610120300848-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1162365-
Descrição: dc.descriptionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by a high mortality of elderly men with age-related comorbidities. In most of these patients, uncontrolled local and systemic hyperinflammation induces severe and often lethal outcomes. The aging process is characterized by the gradual development of a chronic subclinical systemic inflammation (inflamm-aging) and by acquired immune system impairment (immune senescence). Here, we advance the hypothesis that four well-recognized features of aging contribute to the disproportionate SARS-CoV-2 mortality suffered by elderly men: i. the presence of subclinical systemic inflammation without overt disease, ii. a blunted acquired immune system and type I interferon response due to the chronic inflammation; iii. the downregulation of ACE2 (i.e. the SARS-CoV-2 receptor); and iv. accelerated biological aging. The high mortality rate of SARS-CoV-2 infection suggests that clarification of the mechanisms of inflamm-aging and immune senescence can help combat not only age-related disorders but also SARS-CoV-2 infection.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCytokine & Growth Factor Reviews-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectInterleukin-6-
Palavras-chave: dc.subjectCardiovascular diseases-
Palavras-chave: dc.subjectInflamm-aging-
Palavras-chave: dc.subjectHost-directed therapies-
Título: dc.titleInflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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