Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMorari, Joseane-
Autor(es): dc.creatorAnhe, Gabriel F.-
Autor(es): dc.creatorNascimento, Lucas F.-
Autor(es): dc.creatorMoura, Rodrigo F. de-
Autor(es): dc.creatorRazolli, Daniela-
Autor(es): dc.creatorSolon, Carina-
Autor(es): dc.creatorGuadagnini, Dioze-
Autor(es): dc.creatorSouza, Gabriela-
Autor(es): dc.creatorMattos, Alexandre H.-
Autor(es): dc.creatorTobar, Natalia-
Autor(es): dc.creatorRamos, Celso D.-
Autor(es): dc.creatorPascoal, Vinicius D.-
Autor(es): dc.creatorSaad, Mario J.-
Autor(es): dc.creatorLopes-Cendes, Iscia-
Autor(es): dc.creatorMoraes, Juliana C.-
Autor(es): dc.creatorVelloso, Licio A.-
Data de aceite: dc.date.accessioned2026-02-09T12:29:25Z-
Data de disponibilização: dc.date.available2026-02-09T12:29:25Z-
Data de envio: dc.date.issued2021-01-03-
Data de envio: dc.date.issued2021-01-03-
Data de envio: dc.date.issued2014-11-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45959-
Fonte completa do material: dc.identifierhttps://diabetes.diabetesjournals.org/content/63/11/3770-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1162329-
Descrição: dc.descriptionHypothalamic inflammation is a common feature of experimental obesity. Dietary fats are important triggers of this process, inducing the activation of toll-like receptor-4 (TLR4) signaling and endoplasmic reticulum stress. Microglia cells, which are the cellular components of the innate immune system in the brain, are expected to play a role in the early activation of diet-induced hypothalamic inflammation. Here, we use bone marrow transplants to generate mice chimeras that express a functional TLR4 in the entire body except in bone marrow–derived cells or only in bone marrow–derived cells. We show that a functional TLR4 in bone marrow–derived cells is required for the complete expression of the diet-induced obese phenotype and for the perpetuation of inflammation in the hypothalamus. In an obesity-prone mouse strain, the chemokine CX3CL1 (fractalkine) is rapidly induced in the neurons of the hypothalamus after the introduction of a high-fat diet. The inhibition of hypothalamic fractalkine reduces diet-induced hypothalamic inflammation and the recruitment of bone marrow–derived monocytic cells to the hypothalamus; in addition, this inhibition reduces obesity and protects against diet-induced glucose intolerance. Thus, fractalkine is an important player in the early induction of diet-induced hypothalamic inflammation, and its inhibition impairs the induction of the obese and glucose intolerance phenotypes.-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Diabetes Association-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceDiabetes-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectHypothalamic inflammation-
Palavras-chave: dc.subjectGlucose intolerance-
Palavras-chave: dc.subjectObesidade-
Palavras-chave: dc.subjectInflamação hipotalâmica-
Palavras-chave: dc.subjectIntolerância à glicose-
Título: dc.titleFractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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