MiRNAs regulate iron homeostasis in Paracoccidioides brasiliensis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCurcio, Juliana S. de-
Autor(es): dc.creatorOliveira, Lucas Nojosa-
Autor(es): dc.creatorBatista, Mariana P.-
Autor(es): dc.creatorNovaes, Evandro-
Autor(es): dc.creatorSoares, Célia Maria de Almeida-
Data de aceite: dc.date.accessioned2026-02-09T12:28:03Z-
Data de disponibilização: dc.date.available2026-02-09T12:28:03Z-
Data de envio: dc.date.issued2022-05-26-
Data de envio: dc.date.issued2022-05-26-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/50041-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.micinf.2020.10.008-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1161868-
Descrição: dc.descriptionDuring pathogen interaction with the host, several mechanisms are used to favor or inhibit the infectious process; one is called nutritional immunity, characterized by restriction of micronutrients to pathogens. Several studies on fungi of the Paracoccidioides complex, have demonstrated that these pathogens remodel their metabolic pathways to overcome the hostile condition imposed by the host. However, molecular mechanisms that control the regulation of those metabolic changes are not fully understood. Therefore, this work characterizes the expression profile of miRNAs during iron deprivation and describes metabolic pathways putatively regulated by those molecules. Through analysis of RNAseq, 45 miRNAs were identified and eight presented alterations in the expression profile during iron deprivation. Among the differentially regulated miRNAs, five were more abundant in yeast cells during iron deprivation and interestingly, the analyses of genes potentially regulated by those five miRNAs, pointed to metabolic pathways as oxidative phosphorylation, altered in response to iron deprivation. In addition, miRNAs with more abundance in iron presence, have as target genes encoding transcriptional factors related to iron homeostasis and uptake. Therefore, we suggest that miRNAs produced by Paracoccidioides brasiliensis may contribute to the adaptive responses of this fungus in iron starvation environment.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMicrobes and Infection-
Palavras-chave: dc.subjectParacoccidioidomycosis-
Palavras-chave: dc.subjectRNA-Seq-
Palavras-chave: dc.subjectMicroRNA-
Palavras-chave: dc.subjectParacoccidioides brasiliensis-
Palavras-chave: dc.subjectIron-
Palavras-chave: dc.subjectMicoses-
Título: dc.titleMiRNAs regulate iron homeostasis in Paracoccidioides brasiliensis-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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