Superstructure based on β-CD self-assembly induced by a small guest molecule

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Autor(es): dc.creatorSousa, Frederico B. de-
Autor(es): dc.creatorLima, Ana C.-
Autor(es): dc.creatorDenadai, Ângelo M. L.-
Autor(es): dc.creatorAnconi, Cleber P. A.-
Autor(es): dc.creatorAlmeida, Wagner B. de-
Autor(es): dc.creatorNovato, Willian T. G.-
Autor(es): dc.creatorSantos, Hélio F. dos-
Autor(es): dc.creatorDrum, Chester L.-
Autor(es): dc.creatorLanger, Robert-
Autor(es): dc.creatorSinisterra, Rubén D.-
Data de aceite: dc.date.accessioned2026-02-09T12:24:51Z-
Data de disponibilização: dc.date.available2026-02-09T12:24:51Z-
Data de envio: dc.date.issued2017-08-14-
Data de envio: dc.date.issued2017-08-14-
Data de envio: dc.date.issued2012-02-14-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/15155-
Fonte completa do material: dc.identifierhttp://pubs.rsc.org/en/content/articlelanding/2012/cp/c2cp22768a#!divAbstract-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1160820-
Descrição: dc.descriptionThe size, shape and surface chemistry of nanoparticles play an important role in cellular interaction. Thus, the main objective of the present study was the determination of the β-cyclodextrin (β-CD) self-assembly thermodynamic parameters and its structure, aiming to use these assemblies as a possible controlled drug release system. Light scattering measurements led us to obtain the β-CD’s critical aggregation concentration (cac) values, and consequently the thermodynamic parameters of the β-CD spontaneous self-assembly in aqueous solution: ΔaggGo = − 16.31 kJ mol−1, ΔaggHo = − 26.48 kJ mol−1 and TΔaggSo = − 10.53 kJ mol−1 at 298.15 K. Size distribution of the self-assembled nanoparticles below and above cac was 1.5 nm and 60–120 nm, respectively. The number of β-CD molecules per cluster and the second virial coefficient were identified through Debye’s plot and molecular dynamic simulations proposed the three-fold assembly for this system below cac. Ampicillin (AMP) was used as a drug model in order to investigate the key role of the guest molecule in the self-assembly process and the β-CD:AMP supramolecular system was studied in solution, aiming to determine the structure of the supramolecular aggregate. Results obtained in solution indicated that the β-CD’s cac was not affected by adding AMP. Moreover, different complex stoichiometries were identified by nuclear magnetic resonance and isothermal titration calorimetry experiments.-
Idioma: dc.languageen-
Publicador: dc.publisherNational Institute of Health-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourcePhysical Chemistry Chemical Physics-
Palavras-chave: dc.subjectNanoparticles - Surface chemistry-
Palavras-chave: dc.subjectNanopartículas - Química superficial-
Título: dc.titleSuperstructure based on β-CD self-assembly induced by a small guest molecule-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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