Amperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorLourenção, Bruna C.-
Autor(es): dc.creatorMedeiros, Roberta A.-
Autor(es): dc.creatorThomasi, Sérgio Scherrer-
Autor(es): dc.creatorFerreira, Antonio Gilberto-
Autor(es): dc.creatorRocha-Filho, Romeu C.-
Autor(es): dc.creatorFatibello-Filho, Orlando-
Data de aceite: dc.date.accessioned2026-02-09T12:22:15Z-
Data de disponibilização: dc.date.available2026-02-09T12:22:15Z-
Data de envio: dc.date.issued2019-01-25-
Data de envio: dc.date.issued2019-01-25-
Data de envio: dc.date.issued2016-01-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/32511-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0925400515302148#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1159924-
Descrição: dc.descriptionSensitive, simple, low-cost, and rapid amperometric flow-injection methods were developed for determination of ivermectin (IVM) and levamisole (LVM) in anthelmintic pharmaceutical drugs and urine samples. These determinations were carried out with a cathodically (for IVM) or anodically (for LVM) pretreated boron-doped diamond electrode using aqueous 0.5 mol L−1 H2SO4 (with and without addition of 30% V/V of ethanol) as supporting electrolyte. The amperometric detection was performed at an applied electrode potential of E = 1.40 V, for IVM, and E = 1.90 V, for LVM, vs. Ag/AgCl (3.0 mol L−1 KCl). The respective analytical curves presented good linearity in the investigated concentration ranges (0.60–50 μmol L−1, for IVM, and 0.010–5.0 μmol L−1, for LVM) and the detection limits were 0.30 μmol L−1 for IVM, and 1 nmol L−1, for LVM. Investigation of possible interferents showed no significant interference with the here-proposed methods; thus, they were used to determine IVM and LVM in pharmaceutical formulations as well as in urine samples, with results that showed good agreement with comparative methods. Furthermore, a mechanism for LVM electrooxidation was proposed using exhaustive potentiostatic electrolysis and NMR measurements.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceSensors and Actuators B: Chemical-
Palavras-chave: dc.subjectIvermectin-
Palavras-chave: dc.subjectLevamisole-
Palavras-chave: dc.subjectAmperometric detection-
Palavras-chave: dc.subjectElectrochemical pretreatment-
Palavras-chave: dc.subjectIvermectina-
Palavras-chave: dc.subjectDetecção amperométrica-
Palavras-chave: dc.subjectPré-tratamento eletroquímico-
Título: dc.titleAmperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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