Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice

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Autor(es): dc.creatorNogueira, Denise Silva-
Autor(es): dc.creatorOliveira, Luciana Maria de-
Autor(es): dc.creatorAmorim, Chiara Cássia Oliveira-
Autor(es): dc.creatorGazzinelli-Guimarães, Ana Clara-
Autor(es): dc.creatorBarbosa, Fernando Sérgio-
Autor(es): dc.creatorOliveira, Fabrício Marcus Silva-
Autor(es): dc.creatorKraemer, Lucas-
Autor(es): dc.creatorMattos, Matheus-
Autor(es): dc.creatorCardoso, Mariana Santos-
Autor(es): dc.creatorResende, Nathália Maria-
Autor(es): dc.creatorClímaco, Marianna de Carvalho-
Autor(es): dc.creatorNegrão-Corrêa, Deborah Aparecida-
Autor(es): dc.creatorFaria, Ana Maria Caetano-
Autor(es): dc.creatorCaliari, Marcelo Vidigal-
Autor(es): dc.creatorBueno, Lilian Lacerda-
Autor(es): dc.creatorGaze, Soraya-
Autor(es): dc.creatorRusso, Remo Castro-
Autor(es): dc.creatorGuimarães, Pedro Henrique Gazzinelli-
Autor(es): dc.creatorFujiwara, Ricardo Toshio-
Data de aceite: dc.date.accessioned2026-02-09T12:21:05Z-
Data de disponibilização: dc.date.available2026-02-09T12:21:05Z-
Data de envio: dc.date.issued2022-06-27-
Data de envio: dc.date.issued2022-06-27-
Data de envio: dc.date.issued2021-11-15-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/50358-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1159534-
Descrição: dc.descriptionHuman ascariasis is the most prevalent but neglected tropical disease in the world, affecting approximately 450 million people. The initial phase of Ascaris infection is marked by larval migration from the host’s organs, causing mechanical injuries followed by an intense local inflammatory response, which is characterized mainly by neutrophil and eosinophil infiltration, especially in the lungs. During the pulmonary phase, the lesions induced by larval migration and excessive immune responses contribute to tissue remodeling marked by fibrosis and lung dysfunction. In this study, we investigated the relationship between SIgA levels and eosinophils. We found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during Ascaris suum infection. Therefore, control of parasite burden during the pulmonary phase of ascariasis involves eosinophil influx and subsequent promotion of SIgA levels. In addition, we also demonstrate that eosinophils also participate in the process of tissue remodeling after lung injury caused by larval migration, contributing to pulmonary fibrosis and dysfunction in re-infected mice. In conclusion, we postulate that eosinophils play a central role in mediating host innate and humoral immune responses by controlling parasite burden, tissue inflammation, and remodeling during Ascaris suum infection. Furthermore, we suggest that the use of probiotics can induce eosinophilia and SIgA production and contribute to controlling parasite burden and morbidity of helminthic diseases with pulmonary cycles.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherPLOS-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
???dc.source???: dc.sourcePLoS Pathogens-
Palavras-chave: dc.subjectEosinophils-
Palavras-chave: dc.subjectLarvae-
Palavras-chave: dc.subjectParasitic diseases-
Palavras-chave: dc.subjectAscariasis-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectImmune response-
Título: dc.titleEosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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